公开(公告)号：US08557602B2

公开(公告)日：2013-10-15

申请号：US13203959

申请日：2010-02-23

申请人： Atsushi Kuno ,  Jun Hirabayashi ,  Atsushi Matsuda ,  Hisashi Narimatsu ,  Yuzuru Ikehara ,  Junichi Shoda ,  Toru Kawamoto

发明人： Atsushi Kuno ,  Jun Hirabayashi ,  Atsushi Matsuda ,  Hisashi Narimatsu ,  Yuzuru Ikehara ,  Junichi Shoda ,  Toru Kawamoto

IPC分类号： C40B30/04 ,  G01N33/53 ,  G01N33/574

CPC分类号： G01N21/648 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57446

摘要： Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit thereof. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision.

摘要翻译： 公开了一种以简单的方式早期，敏感和可靠地检测和区分主要在肝脏中发生的恶性肿瘤中的肝内胆管癌的方法及其试剂盒。 在该方法中，将由凝血素WFA（Wisteria floribunda凝集素）结合的糖蛋白组成的聚糖生物标志物作为肝内胆管癌的检测用于检测肝内胆管癌的癌症标志物。 检测肝内胆管癌的方法可以明确区分肝内胆管癌与肝细胞癌，能够在适用性，敏感性和准确性方面具有临床可接受的临床诊断和测定能力。

公开(公告)号：US20120065089A1

公开(公告)日：2012-03-15

申请号：US13203959

申请日：2010-02-23

申请人： Atsushi Kuno ,  Jun Hirabayashi ,  Atsushi Matsuda ,  Hisashi Narimatsu ,  Yuzuru Ikehara ,  Junichi Shoda ,  Toru Kawamoto

发明人： Atsushi Kuno ,  Jun Hirabayashi ,  Atsushi Matsuda ,  Hisashi Narimatsu ,  Yuzuru Ikehara ,  Junichi Shoda ,  Toru Kawamoto

IPC分类号： G01N33/574 ,  C40B30/04

CPC分类号： G01N21/648 ,  G01N33/57407 ,  G01N33/57438 ,  G01N33/57446

摘要： Disclosed are a method for early, sensitively and reliably detecting and distinguishing intrahepatic cholangiocarcinoma in a malignant tumor occurring primarily in the liver in a simple way, and a kit therefor. In the method, a glycan biomarker consisting of a lectin WFA (Wisteria floribunda Agglutinin)-binding glycoprotein derived from intrahepatic cholangiocarcinoma is used as a cancer marker to detect intrahepatic cholangiocarcinoma by detecting the cancer marker in a test specimen. The method for detecting intrahepatic cholangiocarcinoma can clearly differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma and enables early detection and determination with a performance clinically acceptable in terms of applicability, sensitivity and precision.

摘要翻译： 公开了一种以简单的方式早期，敏感和可靠地检测和区分主要在肝脏中发生的恶性肿瘤中的肝内胆管癌的方法及其用途。 在该方法中，将由凝血素WFA（Wisteria floribunda凝集素）结合的糖蛋白组成的聚糖生物标志物作为肝内胆管癌的检测用于检测肝内胆管癌的癌症标志物。 检测肝内胆管癌的方法可以明确区分肝内胆管癌与肝细胞癌，能够在适用性，敏感性和准确性方面具有临床可接受的临床诊断和测定能力。