公开(公告)号：US3682895A

公开(公告)日：1972-08-08

申请号：US3682895D

申请日：1970-07-17

申请人： GEORGE R PETTIT ,  DYRAL C FESSIER ,  KENNETH D PAUIL

发明人： PETTIT GEORGE R ,  FESSIER DYRAL C ,  PAUIL KENNETH D

IPC分类号： C07J7/00 ,  C07J9/00 ,  C07J19/00 ,  C07J41/00 ,  C07C173/04

CPC分类号： C07J7/009 ,  C07J7/0095 ,  C07J9/005 ,  C07J19/00 ,  C07J41/0094

摘要： THERE IS PROVIDED A NOVEL METHOD OF SYNTHEESIZING 5ABUFADIENOLIDES, WHICH ARE USEFUL INTERMEDIATES IN THE TOTAL SYNTHESIS OF BUFALIN, A CARDIAC ACTIVE COMPOUND. EPIANDROSTERONE ACETATE IS CONVERTED INTO 3B - ACETOXYL-5APREGNANE-21-AL WHICH UNDERGOES CHAIN EXTENSION TO METHYL 3B-ACETOXYL-20-FORMYL-21-NOR-5A-CHOLANATE WHICH IS RING CLOSED TO FORM THE 3B - ACETOXY-5-A-BUF-20(21)-ENOLIDE WHICH IS DEHYDROGENATED TO THE CORRESPONDING BUFADIENOLIDE.