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公开(公告)号：US20210177796A1
公开(公告)日：2021-06-17
申请号：US16759281
申请日：2018-02-28
发明人： Joung Han YIM , Il-Chan KIM , Se Jong HAN , Ui Joung YOUN , Hyun Cheol OH , Youn-Chul KIM , Jae Hak SOHN , Minh Ha TRAN , Wonmin KO , Seung Jun LEE , Jae-Young SON
IPC分类号： A61K31/335 , A61K36/06 , A23L31/00
摘要： The present invention relates to a pharmaceutical composition for preventing or treating inflammatory diseases and a food for preventing or alleviating inflammatory diseases, both of which contain curvularin-type metabolites as an active ingredient and, more specifically to a pharmaceutical composition for preventing or treating inflammatory diseases and a food for preventing or alleviating inflammatory diseases, both of which contain, as an active ingredient, marine fungus Penicillium sp. SF-5859-derived curvularin-type metabolites. A pharmaceutical composition, according to the present invention, for preventing or treating inflammatory diseases, containing curvularin-type metabolites derived from marine fungus Penicillium sp. SF-5859 (KCTC 13354 BP) inhibits the production of proinflammatory cytokines and mediators, thereby being effectively usable for the prevention or treatment of inflammatory diseases.
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公开(公告)号：US20170304244A1
公开(公告)日：2017-10-26
申请号：US15520100
申请日：2014-10-24
发明人： Joung Han Yim , Il-Chan Kim , Se Jong Han , Dong-Gyu Jo
IPC分类号： A61K31/198
CPC分类号： A61K31/198 , A61K31/167 , A61K31/17 , A61K31/175
摘要： The present invention relates to a neurodegenerative disease treatment use, which is a novel use of Ramalin, and, more specifically, to a composition for preventing or treating neurodegenerative diseases, containing Ramalin, which has an inflammasome and BACE1 expression inhibitory activity. Ramalin according to the present invention has an effect of improving a cognitive ability by inhibiting the expression of an inflammatory factor, which contains an NLRP inflammasome protein, and BACE1, and is thus useful for preventing or treating memory disorder and neurodegenerative diseases.
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