公开(公告)号：US09671481B2

公开(公告)日：2017-06-06

申请号：US13995875

申请日：2011-12-20

申请人： Kamil Ugurbil

发明人： Kamil Ugurbil

IPC分类号： G01R33/54 ,  G01R33/483 ,  G01R33/3415 ,  G01R33/561

CPC分类号： G01R33/543 ,  G01R33/3415 ,  G01R33/4835 ,  G01R33/5612

摘要： A method is provided for substantially simultaneously manipulating spins in a plurality of slice locations using a magnetic resonance imaging (“MRI”) system that includes a radio frequency (“RF”) coil array composed of a plurality of RF coil elements, and in which power deposition, which may be measured as specific absorption rate (“SAR”), is reduce A plurality of slice locations to be substantially simultaneously manipulated with the MRI system are selected, and an RF transmission map (B1+map) is provided for each of the plurality of RF coil elements. A subset of slice locations to be manipulated by each of the RF coil elements is then selected using the provided RF transmission maps. Using the selected subsets of slice locations, an RF pulse to be transmitted by each of the RF coil elements is designed. The designed RF pulses are then substantially simultaneously transmitted by the MRI system to substantially simultaneously manipulate spins in each o the plurality of slice locations.

公开(公告)号：US20130342206A1

公开(公告)日：2013-12-26

申请号：US13995869

申请日：2011-12-20

申请人： Kamil Ugurbil

发明人： Kamil Ugurbil

IPC分类号： G01R33/561

CPC分类号： G01R33/561 ,  G01R33/4835 ,  G01R33/5602

摘要： A method for acquiring image data from a plurality of slice locations in a subject with a magnetic resonance imaging (MRI) system is provided. The method includes directing the MRI system to perform a pulse sequence that includes performing a contrast preparation module configured to generate contrast-encoded longitudinal magnetization and an image encoding module configured to acquire image data from multiple slice locations substantially simultaneously. The contrast preparation module generally includes tipping longitudinal magnetization into the transverse plane to produce transverse magnetization, generating contrast-prepared transverse magnetization by establishing an image contrast in the transverse magnetization, and tipping the contrast-prepared magnetization back along the longitudinal axis to produce the contrast-encoded longitudinal magnetization.

摘要翻译： 提供了一种利用磁共振成像（MRI）系统从受试者的多个切片位置获取图像数据的方法。 该方法包括引导MRI系统执行脉冲序列，该脉冲序列包括执行配置成生成对比度编码的纵向磁化的对比度准备模块和被配置为基本上同时从多个切片位置获取图像数据的图像编码模块。 造影剂制备模块通常包括将纵向磁化倾斜到横向平面中以产生横向磁化，通过在横向磁化中建立图像对比度产生对比度制备的横向磁化，以及沿着纵轴倾斜对比度制备的磁化以产生对比度 - 编码纵向磁化。

公开(公告)号：US20110182920A2

公开(公告)日：2011-07-28

申请号：US12867056

申请日：2009-02-13

申请人： Kamil UGURBIL ,  Deepti JHA ,  Jorn ENGELMANN ,  Ritu MISHRA ,  Karl-Heinz WEISMULLER

发明人： Kamil UGURBIL ,  Deepti JHA ,  Jorn ENGELMANN ,  Ritu MISHRA ,  Karl-Heinz WEISMULLER

IPC分类号： A61K39/00 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/00 ,  C07K7/06 ,  C12Q1/68 ,  A61K38/08 ,  A61P35/00 ,  A61P3/10 ,  A61P31/00 ,  A61P29/00 ,  A61P37/00

CPC分类号： C07K14/46 ,  C07K7/06 ,  C07K2319/01

摘要： The present invention relates to a nucleic acid molecule encoding a peptide capable of being internalized into a cell, wherein said nucleic acid molecule consists of (a) a nucleic acid molecule encoding a peptide having the amino acid sequence of SEQ ID NO: 2; (b) a nucleic acid molecule having the DNA sequence of SEQ ID NO: 1, wherein T is U if the nucleic acid molecule is RNA; or (d) a nucleic acid molecule encoding a peptide having at least 80% sequence identity with that of SEQ ID NO: 2, wherein at least at two positions selected from the group consisting of positions 1, 7 and 8 of SEQ ID NO: 2 a cysteine is present and wherein at least at four positions selected from the groups consisting of position 2, 4, 6, 9 or 10 of SEQ ID NO: 2 an arginine or a lysine is present. The present invention also relates to a peptide encoded by the nucleic acid of the invention, a fusion molecule comprising the peptide of the invention and a composition comprising the peptide or the fusion molecule of the invention. Furthermore, the present invention relates to a method of detecting the internalization behaviour of a fusion molecule of the invention, the composition of the invention for treating and/or preventing a condition selected from cancer, enzyme deficiency diseases, infarcts, cerebral ischemia, diabetes, inflammatory diseases, infections such as bacterial, viral or fungal infections, autoimmune diseases such as systemic lupus erythematodes (SLE) or rheumatoid arthritis, diseases with amyloid-like fibrils such as Alzheimer's disease (AD) and Parkinson's disease (PD) or certain forms of myopathy.

摘要翻译： 本发明涉及编码能够内化到细胞中的肽的核酸分子，其中所述核酸分子由（a）编码具有SEQ ID NO：2的氨基酸序列的肽的核酸分子组成; （b）具有SEQ ID NO：1的DNA序列的核酸分子，其中如果核酸分子是RNA，则T为U; 或（d）编码与SEQ ID NO：2具有至少80％序列同一性的肽的核酸分子，其中至少选自SEQ ID NO：2的第1,7和8位的两个位置。 2存在半胱氨酸，并且其中至少在选自SEQ ID NO：2的位置2,4,6,9或10的四个位置存在精氨酸或赖氨酸。 本发明还涉及由本发明的核酸编码的肽，包含本发明的肽的融合分子和包含本发明的肽或融合分子的组合物。 此外，本发明涉及检测本发明的融合分子的内在行为的方法，本发明的组合物用于治疗和/或预防选自癌症，酶缺乏症，梗死，脑缺血，糖尿病， 炎性疾病，细菌，病毒或真菌感染等感染，自身免疫性疾病如系统性红斑狼疮（SLE）或类风湿性关节炎，具有淀粉状样原纤维的疾病如阿尔茨海默病（AD）和帕金森病（PD）或某些形式的 肌病。

公开(公告)号：US20060255806A1

公开(公告)日：2006-11-16

申请号：US11415366

申请日：2006-05-01

申请人： J. Vaughan ,  Gregor Adriany ,  Kamil Ugurbil

发明人： J. Vaughan ,  Gregor Adriany ,  Kamil Ugurbil

IPC分类号： G01V3/00

CPC分类号： G01R33/34046 ,  G01R33/3453

摘要： An apparatus comprises a radio frequency magnetic field unit to generate a desired magnetic field. In one embodiment, the radio frequency magnetic field unit includes a first aperture that is substantially unobstructed and a second aperture contiguous to the first aperture. In an alternative embodiment, the radio frequency magnetic field unit includes a first side aperture, a second side aperture and one or more end apertures. In one embodiment of a method, a current element is removed from a radio frequency magnetic field unit to form a magnetic field unit having an aperture. In an alternative embodiment, two current elements located opposite from one another in a radio frequency magnetic field unit are removed to form a magnetic filed unit having a first side aperture and a second side aperture.

摘要翻译： 一种装置包括用于产生期望磁场的射频磁场单元。 在一个实施例中，射频磁场单元包括基本无障碍的第一孔和与第一孔邻接的第二孔。 在替代实施例中，射频磁场单元包括第一侧孔，第二侧孔和一个或多个端孔。 在一种方法的一个实施例中，从射频磁场单元移除电流元件以形成具有孔径的磁场单元。 在替代实施例中，移除在射频磁场单元中彼此相对定位的两个电流元件，以形成具有第一侧孔和第二侧孔的磁场单元。

公开(公告)号：US20050116715A1

公开(公告)日：2005-06-02

申请号：US10957870

申请日：2004-10-04

申请人： J. Vaughan ,  Gregor Adriany ,  Kamil Ugurbil ,  John Strupp ,  Peter Andersen

发明人： J. Vaughan ,  Gregor Adriany ,  Kamil Ugurbil ,  John Strupp ,  Peter Andersen

IPC分类号： G01R33/32 ,  G01R33/34 ,  G01R33/3415 ,  G01V3/00 ,  G21K20060101

CPC分类号： G01R33/34046 ,  G01R33/246 ,  G01R33/3415

摘要： An excitation and detection circuit having individually controllable elements for use with a multi-element radio frequency coil. Characteristics of the driving signal, including, for example, the phase, amplitude, frequency and timing, from each element of the circuit is separately controllable using small signals. Negative feedback for the driving signal associated with each coil element is derived from a receiver coupled to that coil element.

摘要翻译： 激励和检测电路具有用于与多元件射频线圈一起使用的独立可控元件。 来自电路的每个元件的驱动信号的特性，包括例如相位，幅度，频率和定时的特性可以使用小信号单独控制。 与每个线圈元件相关联的驱动信号的负反馈从耦合到该线圈元件的接收器导出。

公开(公告)号：US08941381B2

公开(公告)日：2015-01-27

申请号：US13118179

申请日：2011-05-27

申请人： David Feinberg ,  Kamil Ugurbil

发明人： David Feinberg ,  Kamil Ugurbil

IPC分类号： G01R33/561 ,  G01R33/483

CPC分类号： G01R33/4835 ,  G01R33/561 ,  G01R33/5611 ,  G01R33/5615

摘要： Disclosed are methods and systems for carrying out super-multiplexed magnetic resonance imaging that entwines techniques previously used individually and independently of each other in Simultaneous Echo (or Imaging) Refocusing (SER or SIR) and Multi-Band (MB) excitation, in a single pulse sequence that provides a multiplication rather than summation of desirable effects while suppressing undesirable effects of each of the techniques that previously were used independently.

摘要翻译： 公开了用于执行超多重磁共振成像的方法和系统，其在单次同时回波（或成像）重聚焦（SER或SIR）和多频带（MB）激励中单独地并且彼此独立地相互交织， 脉冲序列提供乘法而不是期望效应的求和，同时抑制先前独立使用的每种技术的不期望的影响。

公开(公告)号：US20130342200A1

公开(公告)日：2013-12-26

申请号：US13995875

申请日：2011-12-20

申请人： Kamil Ugurbil

发明人： Kamil Ugurbil

IPC分类号： G01R33/54

CPC分类号： G01R33/543 ,  G01R33/3415 ,  G01R33/4835 ,  G01R33/5612

摘要： A method is provided for substantially simultaneously manipulating spins in a plurality of slice locations using a magnetic resonance imaging [“MRI”) system that includes a radio frequency (“RF”) coil array composed of a plurality of RF coil dements, and in which power deposition, which may be measured as specific absorption rate (“SAR”), is reduce A plurality of slice locations to be substantially simultaneously manipulated with the MRI system are selected, and an RF transmission map (B1+ map) is provided for each of the plurality of RF coil elements. A subset of slice locations to be manipulated by each of the RF coil elements is then selected using the provided RF transmission maps. Using the selected subsets of slice locations, an RF pulse to be transmitted by each of the RF coil elements is designed. The designed RF pulses are then substantially simultaneously transmitted by the MRI system to substantially simultaneously manipulate spins in each o the plurality of slice locations.

摘要翻译： 提供了一种用于使用包括由多个RF线圈衍射构成的射频（“RF”）线圈阵列的磁共振成像（“MRI”）系统基本上同时操作多个切片位置中的自旋的方法，其中 可以作为特定吸收率（“SAR”）测量的功率沉积被选择为选择与MRI系统基本上同时操作的多个切片位置，并且为每个切片位置提供RF传输图（B1 + map） 多个RF线圈元件。 然后使用所提供的RF传输图来选择要由每个RF线圈元件操纵的切片位置的子集。 使用所选择的切片位置子集，设计要由每个RF线圈元件发送的RF脉冲。 所设计的RF脉冲然后由MRI系统基本上同时传输，以基本上同时操纵多个切片位置中的每一个的自旋。

公开(公告)号：US07598739B2

公开(公告)日：2009-10-06

申请号：US10420541

申请日：2003-04-21

申请人： John Thomas Vaughan, Jr. ,  Kamil Ugurbil ,  Gregor Adriany

发明人： John Thomas Vaughan, Jr. ,  Kamil Ugurbil ,  Gregor Adriany

IPC分类号： G01V3/00

CPC分类号： G01R33/34046 ,  G01R33/345 ,  G01R33/3628 ,  G01R33/3635

摘要： A plurality of linear current elements are configured about a specimen to be imaged. A current in each current element is controlled independent of a current in other current elements to select a gradient and to provide radio frequency shimming. Each current element is driven by a separate channel of a transmitter and connected to a separate channel of a multi-channel receiver. The impedance, and therefore, the current, in each current element is controlled mechanically or electrically.

摘要翻译： 多个线性电流元件围绕待成像的样本配置。 每个电流元件中的电流独立于其它电流元件中的电流被控制以选择梯度并提供射频匀场。 每个电流元件由发射器的单独信道驱动，并连接到多通道接收器的单独信道。 每个电流元件中的阻抗以及因此的电流被机械或电气控制。

公开(公告)号：US20080084210A1

公开(公告)日：2008-04-10

申请号：US11858707

申请日：2007-09-20

申请人： J. Vaughan ,  Gregor Adriany ,  Carl Snyder ,  Can Akgun ,  Jinfeng Tian ,  Kamil Ugurbil ,  Pierre-Francois Van de Moortele ,  Steen Moeller

发明人： J. Vaughan ,  Gregor Adriany ,  Carl Snyder ,  Can Akgun ,  Jinfeng Tian ,  Kamil Ugurbil ,  Pierre-Francois Van de Moortele ,  Steen Moeller

IPC分类号： G01R33/28

CPC分类号： G01R33/3415 ,  G01R33/34046

摘要： A current unit having two or more current paths allows control of magnitude, phase, time, frequency and position of each of element in a radio frequency coil. For each current element, the current can be adjusted as to a phase angle, frequency and magnitude. Multiple current paths of a current unit can be used for targeting multiple spatial domains or strategic combinations of the fields generated/detected by combination of elements for targeting a single domain in magnitude, phase, time, space and frequency.

摘要翻译： 具有两个或多个电流路径的电流单元允许控制射频线圈中每个元件的幅度，相位，时间，频率和位置。 对于每个电流元件，电流可以调整为相位角，频率和幅度。 可以使用当前单元的多个电流路径来瞄准多个空间域或通过用于在幅度，相位，时间，空间和频率上针对单个域的元件组合生成/检测的场的策略组合。

公开(公告)号：US20060006865A1

公开(公告)日：2006-01-12

申请号：US11224436

申请日：2005-09-12

申请人： Xiaoliang Zhang ,  Kamil Ugurbil ,  Wei Chen

发明人： Xiaoliang Zhang ,  Kamil Ugurbil ,  Wei Chen

IPC分类号： G01V3/00

CPC分类号： H01Q17/00 ,  G01R33/34007 ,  G01R33/345 ,  Y10T29/4902 ,  Y10T29/49073

摘要： Apparatus and method for MRI imaging using a coil constructed of microstrip transmission line (MTL coil) are disclosed. In one method, a target is positioned to be imaged within the field of a main magnetic field of a magnet resonance imaging (MRI) system, a MTL coil is positioned proximate the target, and a MRI image is obtained using the main magnet and the MTL coil. In another embodiment, the MRI coil is used for spectroscopy. MRI imaging and spectroscopy coils are formed using microstrip transmission line. These MTL coils have the advantageous property of good performance while occupying a relatively small space, thus allowing MTL coils to be used inside restricted areas more easily than some other prior art coils. In addition, the MTL coils are relatively simple to construct of inexpensive components and thus relatively inexpensive compared to other designs. Further, the MTL coils of the present invention can be readily formed in a wide variety of coil configurations, and used in a wide variety of ways. Further, while the MTL coils of the present invention work well at high field strengths and frequencies, they also work at low frequencies and in low field strengths as well.