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公开(公告)号:US20110064740A1
公开(公告)日:2011-03-17
申请号:US12679917
申请日:2008-09-23
申请人: Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: A61K39/395 , C07K16/00 , A61P27/02
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要: The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterised by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译: 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法,其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物,特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成, 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白,特别是人和淀粉样蛋白肽。
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公开(公告)号:US20140050719A1
公开(公告)日:2014-02-20
申请号:US13491810
申请日:2012-06-08
申请人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K. Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K. Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: C07K16/18
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译: 结合人β-淀粉样蛋白肽的抗体,用所述抗体治疗特征为升高的β-淀粉样蛋白水平或β-淀粉样沉积物的疾病或病症的方法,包含所述抗体的药物组合物和制备方法。
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公开(公告)号:US09193784B2
公开(公告)日:2015-11-24
申请号:US13491810
申请日:2012-06-08
申请人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: C07K16/18 , A61K39/395 , A61K39/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterized by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译: 结合人和淀粉样蛋白肽的抗体,以所述抗体为特征的疾病或病症的特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物的方法,包含所述抗体的药物组合物和制备方法。
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公开(公告)号:US20140038957A1
公开(公告)日:2014-02-06
申请号:US13994691
申请日:2011-12-15
申请人: David R. Witty , David Norton , Jason Paul Tierney , Ghislaine Lorthioir , Mairi Sime , Karen Louise Philpott
发明人: David R. Witty , David Norton , Jason Paul Tierney , Ghislaine Lorthioir , Mairi Sime , Karen Louise Philpott
IPC分类号: C07D487/04
CPC分类号: C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , C07D401/04 , C07D401/14
摘要: This invention relates to pyrrolopyrimidine derivatives of formula (I): where R1, X, p, R4, R2 and R3 are as defined herein, and their use as pharmaceuticals.
摘要翻译: 本发明涉及式(I)的吡咯并嘧啶衍生物:其中R1,X,p,R4,R2和R3如本文所定义,及其作为药物的用途。
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公开(公告)号:US08227576B2
公开(公告)日:2012-07-24
申请号:US12294438
申请日:2007-03-27
申请人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Jonathan Henry Ellis , Susannah K Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: C12P21/08 , C07K16/00 , A61K39/395 , A61K39/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/34 , C07K2317/52 , C07K2317/71 , C07K2317/92 , C07K2317/94
摘要: Antibodies that bind human β-amyloid peptide, methods of treating diseases or disorders characterised by elevated β-amyloid levels or β-amyloid deposits with said antibodies, pharmaceutical compositions comprising said antibodies and methods of manufacture.
摘要翻译: 结合人和淀粉样蛋白肽的抗体,以所述抗体为特征的疾病或病症的特征在于淀粉样蛋白水平升高或淀粉样沉积的方法,包含所述抗体的药物组合物和制造方法。
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公开(公告)号:US09045485B2
公开(公告)日:2015-06-02
申请号:US13994691
申请日:2011-12-15
申请人: David R. Witty , David Norton , Jason Paul Tierney , Ghislaine Lorthioir , Mairi Sime , Karen Louise Philpott
发明人: David R. Witty , David Norton , Jason Paul Tierney , Ghislaine Lorthioir , Mairi Sime , Karen Louise Philpott
IPC分类号: C07D401/04 , C07D401/14 , C07D487/04 , A61K31/4523 , A61K31/519 , A61P19/02
CPC分类号: C07D487/04 , A61K31/4523 , A61K31/519 , A61K31/5377 , C07D401/04 , C07D401/14
摘要: This invention relates to pyrrolopyrimidine derivatives of formula (I): where R1, X, p, R4, R2 and R3 are as defined herein, and their use as pharmaceuticals.
摘要翻译: 本发明涉及式(I)的吡咯并嘧啶衍生物:其中R1,X,p,R4,R2和R3如本文所定义,及其作为药物的用途。
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公开(公告)号:US08858943B2
公开(公告)日:2014-10-14
申请号:US12679917
申请日:2008-09-23
申请人: Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
发明人: Stephen Anthony Burbidge , Ian Richard Catchpole , Jonathan Henry Ellis , Susannah Karen Ford , Volker Germaschewski , Umesh Kumar , Karen Louise Philpott , Peter Ernest Soden
IPC分类号: A61K39/395 , A61K35/30 , A61K35/44 , C07K16/18 , A61K39/00
CPC分类号: C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/567
摘要: The present invention relates to methods of treating diseases or disorders affecting the eye or optic nerve characterized by elevated β-amyloid levels or β-amyloid deposits, particularly age related macular degeneration and glaucoma type diseases and β-amyloid dependent cataract formation, with antigen binding proteins that bind β-amyloid peptide and in particular human β-amyloid peptide.
摘要翻译: 本发明涉及治疗影响眼睛或视神经的疾病或病症的方法,其特征在于升高的淀粉样蛋白水平或淀粉样蛋白沉积物,特别是年龄相关性黄斑变性和青光眼型疾病和淀粉样蛋白依赖性白内障形成, 具有结合β-淀粉样蛋白肽的特异性抗原结合蛋白,特别是人和淀粉样蛋白肽。
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