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1.发明授权Certain bicycloalkane and azabicycloalkane-1,1-diphosphonic acid derivatives useful for treating diseases associated with abnormal calcium and phosphate metabolism 失效某些用于治疗与钙和磷酸盐代谢异常有关的疾病的双环烷烃和氮杂双环链烷-1,1-二膦酸衍生物
公开(公告)号：US5104863A
公开(公告)日：1992-04-14
申请号：US547646
申请日：1990-07-03
CPC分类号： C07F9/3856 , C07F9/3852 , C07F9/5765
摘要： This invention relates to pyrindine-diphosphonic acid derivatives which are useful in treating or preventing diseases characterized by abnormal calcium and phosphate matabolism, in particular those which are characterized by abnormal bone metabolism. This invention further relates to pharmaceutical compositions which contain the novel compounds of the present invention, and to a method of treating or preventing diseases characterized by abnormal calcium and phosphate metabolism utilizing a compound of the present invention.
摘要翻译： 本发明涉及嘧啶二膦酸衍生物，其可用于治疗或预防以异常钙和磷酸盐分解为特征的疾病，特别是以异常骨代谢为特征的疾病。 本发明还涉及含有本发明新化合物的药物组合物，以及利用本发明化合物治疗或预防以异常钙和磷酸盐代谢为特征的疾病的方法。
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2.发明授权Certain hexahydroindan-2,2-diphosphonic acids useful in treating diseases associated with abnormal calcium and phosphate metabolism 失效某些六氢茚满-2,2-二膦酸可用于治疗与钙和磷酸盐代谢异常有关的疾病
公开(公告)号：US4687768A
公开(公告)日：1987-08-18
申请号：US684544
申请日：1984-12-21
IPC分类号： A61K31/66 , A61K31/675 , A61P3/00 , A61P3/02 , A61P3/14 , A61P19/10 , A61P43/00 , C07F9/38 , C07F9/40 , C07F9/547 , C07F9/576 , C07F9/58
CPC分类号： C07F9/3852 , C07F9/3856 , C07F9/5765
摘要： Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate metabolism; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these noval cyclic diphosphonic acid compounds.
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3.发明授权Certain cycloalkane-1,1-diphosphonic acids and derivatives thereof having the ability to treat diseases associated with abnormal calcium and phosphate metabolism 失效某些具有治疗与异常钙和磷酸盐代谢相关疾病的能力的环烷-1,1-二膦酸及其衍生物
公开(公告)号：US4939131A
公开(公告)日：1990-07-03
申请号：US85906
申请日：1987-08-14
IPC分类号： A61K31/66 , A61K31/675 , A61P3/00 , A61P3/02 , A61P3/14 , A61P19/10 , A61P43/00 , C07F9/38 , C07F9/40 , C07F9/547 , C07F9/576 , C07F9/58
CPC分类号： C07F9/3852 , C07F9/3856 , C07F9/5765
摘要： Novel cyclic geminal-diphosphonic acid compounds, and pharmaceutical compositions containing these compounds, which are useful for treating diseases characterized by abnormal calcium and phosphate metabolism; and a method of treating diseases characterized by abnormal calcium and phosphate metabolism utilizing these novel cyclic diphosphonic acid compounds.
摘要翻译： 新型环状偕二膦酸化合物和含有这些化合物的药物组合物，其可用于治疗以钙和磷酸钙代谢异常为特征的疾病; 以及利用这些新型环状二膦酸化合物治疗以异常钙和磷酸盐代谢为特征的疾病的方法。
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