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1.
公开(公告)号:US20120135019A1
公开(公告)日:2012-05-31
申请号:US13283452
申请日:2011-10-27
申请人: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
CPC分类号: C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要: The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.
摘要翻译: 本发明涉及可用于降低针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外,该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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2.
公开(公告)号:US08969524B2
公开(公告)日:2015-03-03
申请号:US13283452
申请日:2011-10-27
申请人: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
发明人: Katharina Nora Steinitz , Paula Maria Wilhelmina van Helden , Birgit Maria Reipert , Hans-Peter Schwarz , Hartmut Ehrlich
IPC分类号: A61K38/37 , C07K14/745 , G01N33/50
CPC分类号: C07K14/755 , A61K38/37 , C07K2319/00 , C12P21/00 , G01N33/505 , G01N33/56977
摘要: The present invention is related to peptides that can be used to reduce the immune response against FVIII or to induce tolerance to human FVIII in patients with, e.g., hemophilia A. Furthermore, the peptides can be used for immunodiagnostic purposes to detect FVIII-specific CD4+ T cells to monitor patients with hemophilia A during replacement therapy and during immune tolerance induction therapy.
摘要翻译: 本发明涉及可用于降低针对FVIII的免疫应答或诱导对例如血友病A的患者对人FVIII的耐受性的肽。此外,该肽可用于免疫诊断目的以检测FVIII-特异性CD4 + T细胞在替代治疗期间和免疫耐受诱导治疗期间监测血友病A患者。
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