公开(公告)号：US4220778A

公开(公告)日：1980-09-02

申请号：US956467

申请日：1978-10-30

申请人： Charles R. Ellefson ,  Kathleen Prodan

发明人： Charles R. Ellefson ,  Kathleen Prodan

IPC分类号： C07D217/02 ,  C07D217/04 ,  C07D217/24 ,  C07D263/12 ,  C07D263/14 ,  C07D311/76 ,  C07D217/18

CPC分类号： C07D217/24 ,  C07D217/02 ,  C07D217/04 ,  C07D263/12 ,  C07D263/14 ,  C07D311/76 ,  Y10S514/821

摘要： 8-Aryl-1,2,3,4-tetrahydroisoquinoline and derivatives thereof having the formula ##STR1## and the non-toxic pharmacologically acceptable acid addition salts thereof; wherein R is hydrogen, benzyl, or an alkyl radical of 1 to 7 carbon atoms; R.sup.1 is hydrogen or an alkyl radical of 1 to 7 carbon atoms; R.sup.2 in each occurrence is hydrogen, an alkyl radical of 1 to 7 carbon atoms or alkoxy radical of 1 to 7 carbon atoms, alike or different; Ar is phenyl optionally substituted with one or more halogen, an alkyl radical of 1 to 7 carbon atoms, or alkoxy radical of 1 to 7 carbon atoms; and n is positive integer less than 4, are disclosed. These compounds are useful because of their anti-arrhythmic, antimicrobial and central nervous system activity.

摘要翻译： 具有式“IMAGE”的8-芳基-1,2,3,4-四氢异喹啉及其衍生物及其无毒的药理学上可接受的酸加成盐; 其中R为氢，苄基或1至7个碳原子的烷基; R1是氢或1至7个碳原子的烷基; R 2在每次出现时是氢，1至7个碳原子的烷基或1至7个碳原子的烷氧基，相同或不同; Ar是任选被一个或多个卤素，1至7个碳原子的烷基或1至7个碳原子的烷氧基取代的苯基; 并且n是小于4的正整数。 这些化合物由于其抗心律不齐，抗微生物和中枢神经系统活性而有用。