公开(公告)号：US06346086B1

公开(公告)日：2002-02-12

申请号：US09298212

申请日：1999-04-23

申请人： John A. Maksem ,  Rodney W. Bosley, Jr. ,  Kathren J. Sips

发明人： John A. Maksem ,  Rodney W. Bosley, Jr. ,  Kathren J. Sips

IPC分类号： A61B1000

CPC分类号： A61B10/0291 ,  A61B2010/0216

摘要： A medical device 10 for collecting both endocervical cells and exocervical cells from a human or veterinary patient includes an elongate handle 12 having first and second handle ends 14 and 16, an elongate foam portion 18 carried by one of the handle ends 14 or 16, and a disk-like foam portion 19 carried by either the same or the opposite handle end 14 or 16. The device 10 includes at least one base plate 30 or 32 connected to the handle 12, to which the elongate and disk-like foam portions 18 and 19 are affixed. The elongate foam portion 18 can be cylindrical in shape, while the disk-like portion 19 can be a convex disk 20 or a generally flat disk 60 or 80. The first foam portion 18 is positioned about a tip 40 or 48 carried by the first handle end 14, for example, connected to the first base plate 30. The first and second foam portions 18 and 19 can be carried on opposite ends 14 and 16 of the handle 12, or can be unitarily formed as a single foam portion 22 carried by the first handle end 14. The foam portions 18, 19, 20, 22, 60 and/or 80 comprise an open cell, reticulated foam (such as a polyester polyurethane foam of relatively large mean pore diameter, for example, 1 mm or larger) which is sufficiently pliant to take the shape of the internal and external surfaces of the cervix and is sufficiently abrasive to scrape an acceptably large number of cells from the internal and external surfaces of the cervix during use. In an alternative embodiment, the handle 12 includes a lumen 65 defined therein which is dimensioned to receive an endocervical brush 84 or other structure or object 82 therein, such as a guide wire, an endoscope, an optical fiber or a sensor. The device 10 can include the brush 84 or other object 82. The foam portion in that embodiment is preferably a perforate disk 80. The device 10 enjoys a superior combination of cell capture and relative patient comfort.

摘要翻译： 用于收集人或兽医患者的子宫颈癌细胞和子宫颈细胞的医疗装置10包括具有第一和第二手柄端14和16的细长手柄12，由手柄端14或16之一承载的细长泡沫部分18和 由相同或相对的手柄端14或16承载的盘状泡沫部分19.装置10包括连接到手柄12的至少一个基板30或32，细长和盘状泡沫部分18 和19个。 细长泡沫部分18可以是圆柱形的，而盘状部分19可以是凸形盘20或大致平坦的盘60或80.第一泡沫部分18围绕尖端40或48定位，第一 手柄端14例如连接到第一底板30.第一和第二泡沫部分18和19可以被承载在手柄12的相对端14和16上，或者可以一体地形成为携带的单个泡沫部分22 泡沫部分18,19,20,22,60和/或80包括开孔，网状泡沫（例如平均孔径相对较大的聚酯聚氨酯泡沫，例如1mm或 较大），其足够柔韧以采取子宫颈的内表面和外表面的形状，并且在使用期间足够磨蚀以从子宫颈的内表面和外表面刮掉可接受的大量细胞。 在替代实施例中，手柄12包括限定在其中的内腔65，其尺寸被设计成容纳子宫颈内刷84或其中的其它结构或物体82，例如导丝，内窥镜，光纤或传感器。 装置10可以包括刷84或其它物体82.该实施例中的泡沫部分优选是穿孔盘80.装置10具有细胞捕获和

公开(公告)号：US06527752B1

公开(公告)日：2003-03-04

申请号：US09669315

申请日：2000-09-25

申请人： Rodney W. Bosley, Jr. ,  Kathren J. Sips

发明人： Rodney W. Bosley, Jr. ,  Kathren J. Sips

IPC分类号： A16M25098

CPC分类号： A61B17/435 ,  A61B17/43 ,  A61B2090/3925 ,  A61D19/04 ,  A61M25/0054

摘要： A cellular transfer catheter (10) is provided for implantation of cellular material into the uterus of a patient. The catheter includes a first component (11, 13) of a first material (26) which has a passageway (16) extending therethrough, and a second component (12) of a second material (27) having a higher durometer than the first material and suitable for assisting passage of the first component (11, 13) through a cervix and into the uterus of the patient. The first component (11, 13) includes a region (20) closely adjacent its distal end (18) having an ultrasonic reflectivity detectably different from the reflectivity of adjacent parts.

摘要翻译： 提供了一种细胞转移导管（10），用于将细胞材料植入患者的子宫。 导管包括具有延伸穿过其中的通道（16）的第一材料（26）的第一部件（11,13）和具有比第一材料更高硬度的第二材料（27）的第二部件（12） 并且适于辅助第一部件（11,13）通过子宫颈并进入患者的子宫中。 第一部件（11,13）包括紧邻其远端（18）的区域（20），其具有与相邻部件的反射率可检测地不同的超声波反射率。