公开(公告)号：US20100311057A1

公开(公告)日：2010-12-09

申请号：US12742032

申请日：2008-11-10

申请人： Ryan Parr ,  Jennifer Creed ,  Kerry Robinson ,  Andrea Maggrah ,  Katrina Maki ,  Gabriel Dakubo ,  Brian Reguly ,  Andrew Harbottle ,  Jude Alexander

发明人： Ryan Parr ,  Jennifer Creed ,  Kerry Robinson ,  Andrea Maggrah ,  Katrina Maki ,  Gabriel Dakubo ,  Brian Reguly ,  Andrew Harbottle ,  Jude Alexander

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to methods for predicting, diagnosing and monitoring cancer. The methods comprise obtaining biological samples, extracting mitochondrial DNA (mtDNA) from the samples, quantifying mitochondrial DNA mutation in the sample and comparing the level of mtDNA mutation with a reference value. The methods of the invention may also be effective in screening for new therapeutic agents and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.

摘要翻译： 本发明涉及预测，诊断和监测癌症的方法。 方法包括获取生物样品，从样品中提取线粒体DNA（mtDNA），定量样品中的线粒体DNA突变，并将mtDNA突变水平与参考值进行比较。 本发明的方法还可以有效地筛选新的治疗剂和治疗方案，并且还可用于监测受试者对预防或治疗性治疗的反应。

公开(公告)号：US20110045471A1

公开(公告)日：2011-02-24

申请号：US12682338

申请日：2008-09-14

申请人： Ryan Parr ,  Mark Birch-Machin ,  Andrew Harbottle ,  Robert Thayer ,  Jennifer Creed ,  Andrea Maggrah ,  Kerry Robinson ,  Gabriel Dakubo ,  Brian Reguly ,  Katrina Maki

发明人： Ryan Parr ,  Mark Birch-Machin ,  Andrew Harbottle ,  Robert Thayer ,  Jennifer Creed ,  Andrea Maggrah ,  Kerry Robinson ,  Gabriel Dakubo ,  Brian Reguly ,  Katrina Maki

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.

摘要翻译： 本发明涉及用于预测，诊断和监测皮肤状态和皮肤疾病的方法。 这些方法将非侵入性皮肤收集技术与一种或多种用于确定线粒体DNA（mtDNA）畸变和黑皮质素1受体（MC1R）变体的测定结合使用，从而提供用于鉴定，预测和/或监测光老化，紫外线 辐射（UVR）损伤或皮肤病。 本发明的方法还可以有效地筛选新的治疗剂，护肤产品和治疗方案，并且还可用于监测受试者对预防或治疗性治疗的反应。

公开(公告)号：US20110201011A2

公开(公告)日：2011-08-18

申请号：US12682338

申请日：2008-10-14

申请人： Ryan PARR ,  Mark BIRCH-MACHIN ,  Andrew HARBOTTLE ,  Robert THAYER ,  Jennifer CREED ,  Andrea MAGGRAH ,  Kerry ROBINSON ,  Gabriel DAKUBO ,  Brian REGULY ,  Katrina MAKI

发明人： Ryan PARR ,  Mark BIRCH-MACHIN ,  Andrew HARBOTTLE ,  Robert THAYER ,  Jennifer CREED ,  Andrea MAGGRAH ,  Kerry ROBINSON ,  Gabriel DAKUBO ,  Brian REGULY ,  Katrina MAKI

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/156

摘要： The present invention relates to methods for predicting, diagnosing and monitoring skin states and skin diseases. The methods combine the use of non-invasive skin collecting techniques with one or more assays for determining mitochondrial DNA (mtDNA) aberrations and Melanocortin 1 Receptor (MC1R) variants, thereby providing a comprehensive tool for identifying, predicting and/or monitoring photoageing, ultraviolet radiation (UVR) damage or skin disease. The methods of the invention may also be effective in screening for new therapeutic agents, skin care products and treatment regimes, and may also be useful for monitoring the response of a subject to a preventative or therapeutic treatment.

摘要翻译： 本发明涉及用于预测，诊断和监测皮肤状态和皮肤疾病的方法。 该方法将非侵入性皮肤收集技术与一种或多种用于确定线粒体DNA（mtDNA）畸变和黑皮质素1受体（MC1R）变体的测定结合使用，从而提供用于鉴定，预测和/或监测光老化，紫外线 辐射（UVR）损伤或皮肤病。 本发明的方法还可以有效地筛选新的治疗剂，护肤产品和治疗方案，并且还可用于监测受试者对预防或治疗性治疗的反应。