公开(公告)号：US20070105765A1

公开(公告)日：2007-05-10

申请号：US10570487

申请日：2004-09-09

申请人： Peter O'Hare ,  Kavitha Sunassee ,  Neil Brewis

发明人： Peter O'Hare ,  Kavitha Sunassee ,  Neil Brewis

IPC分类号： A61K48/00 ,  A61K38/16 ,  C07K14/03

CPC分类号： C07K14/005 ,  A61K38/162 ,  A61K48/00 ,  C12N15/88 ,  C12N2710/16622

摘要： This invention relates to aggregated compositions comprising short peptides, or sub-sequences, of full length VP22 protein for delivery of substances such as nucleic acids and proteins into cells. The invention relates to such compositions in themselves, and to methods for their manufacture and use.

摘要翻译： 本发明涉及包含用于将诸如核酸和蛋白质的物质递送到细胞中的全长VP22蛋白的短肽或亚序列的聚集组合物。 本发明本身涉及这些组合物及其制造和使用方法。

公开(公告)号：US20060189558A1

公开(公告)日：2006-08-24

申请号：US11223449

申请日：2005-09-09

申请人： Peter Francis O'Hare ,  Neil Brewis ,  Nadia Normand ,  Kavitha Sunassee

发明人： Peter Francis O'Hare ,  Neil Brewis ,  Nadia Normand ,  Kavitha Sunassee

IPC分类号： A61K48/00 ,  A61K31/409 ,  A61K31/555

CPC分类号： C07K14/005 ,  A61K48/00 ,  C07K2319/00 ,  C12N15/87 ,  C12N2710/16622

摘要： Aggregates comprising VP22 protein and oligonucleotides or polynucleotides can be used together with a disaggregating agent (simultaneously or sequentially) to treat target cells by delivery of molecules to the cells and/or to prevent cell proliferation and/or to kill cells.