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公开(公告)号：US20120209007A9
公开(公告)日：2012-08-16
申请号：US13201053
申请日：2010-02-11
申请人： Abdul Majeed Seayad , Balamurugam Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga , Manabu Wadamoto
发明人： Abdul Majeed Seayad , Balamurugam Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga , Manabu Wadamoto
IPC分类号： C07D213/57 , C07D333/50 , C07D307/02 , C07F7/28 , C07C253/00
CPC分类号： B01J31/1805 , B01J31/2265 , B01J2231/341 , B01J2531/46 , C07B43/08
摘要： The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.
摘要翻译： 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示：其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及一种氰化氰胺的方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。
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公开(公告)号：US07153523B2
公开(公告)日：2006-12-26
申请号：US10322458
申请日：2002-12-19
CPC分类号： C08G63/06 , A61K9/1647
摘要： A biologically absorbable polyhydroxycarboxylic acid in which a content of water-soluble acid components is not more than 0.07 mol/kg in terms of monobasic acids, and which has a weight average molecular weight of 4,000 to 100,000 and contains neither a catalyst nor an organic solvent, and a production method thereof.
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公开(公告)号：US20100249443A1
公开(公告)日：2010-09-30
申请号：US12679252
申请日：2008-09-26
申请人： Abdul Majeed Seayad , Balamurugan Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga
发明人： Abdul Majeed Seayad , Balamurugan Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga
IPC分类号： C07F7/28 , C07C253/08 , C07C253/30
CPC分类号： C07C253/30 , C07B41/02 , C07B43/08 , C07B53/00 , C07C255/19
摘要： The present invention relates to titanium catalysts for asymmetric synthesis reactions produced by bringing a reaction mixture obtained by contacting water and a titanium alkoxide into contact with an optically active ligand represented by the general formula (a), wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and A* represents a group with two or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for asymmetric cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.
摘要翻译： 本发明涉及通过使水与钛醇盐接触而得到的反应混合物与通式（a）表示的光学活性配体接触而制备的不对称合成反应的钛催化剂，其中R1，R2，R3和R4 独立地为氢原子，烷基等，A *表示具有2个以上具有不对称碳原子或轴向不对称性的碳原子的基团。 本发明还涉及亚胺不对称氰化方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。
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公开(公告)号：US20120088938A1
公开(公告)日：2012-04-12
申请号：US13258735
申请日：2010-03-26
申请人： Manabu Wadamoto , Kazuhiko Yoshinaga , Takushi Nagata , Seayad Abdul Majeed , Ramalingam Balamurugan , Chai Christina L. L.
发明人： Manabu Wadamoto , Kazuhiko Yoshinaga , Takushi Nagata , Seayad Abdul Majeed , Ramalingam Balamurugan , Chai Christina L. L.
IPC分类号： C07C29/14
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/40 , C07C41/30 , C07C2601/14 , C07D213/30 , C07D307/42 , C07C33/46 , C07C33/18 , C07C33/24 , C07C43/23 , C07C33/28 , C07C33/34 , C07C33/20
摘要： Disclosed is a method for producing an optically active alcohol including reacting a titanium compound, an aromatic magnesium compound and a carbonyl compound in the presence of an optically active biphenol compound having a predetermined structure and an ether compound having a predetermined structure.
摘要翻译： 公开了一种光学活性醇的制造方法，其包括在具有预定结构的光学活性联苯酚化合物和具有预定结构的醚化合物的存在下使钛化合物，芳族镁化合物和羰基化合物反应。
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公开(公告)号：US20100185000A1
公开(公告)日：2010-07-22
申请号：US12593643
申请日：2007-09-28
申请人： Abdul Majeed Seayad , Christina Chai , Balamurugan Ramalingam , Takushi Nagata , Kazuhiko Yoshinaga
发明人： Abdul Majeed Seayad , Christina Chai , Balamurugan Ramalingam , Takushi Nagata , Kazuhiko Yoshinaga
IPC分类号： C07C253/30 , C07F7/28 , C07D307/54
CPC分类号： C07C253/30 , C07B41/02 , C07B43/08 , C07B53/00 , C07C255/19
摘要： The present invention relates to titanium catalysts for asymmetric synthesis reactions produced by bringing a reaction mixture obtained by contacting water and a titanium alkoxide into contact with an optically active ligand represented by the general formula (a), wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and A* represents a group with two or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for asymmetric cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.
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6.发明授权公开(公告)号：US07732544B2
公开(公告)日：2010-06-08
申请号：US11665346
申请日：2005-10-06
IPC分类号： C08F2/22
CPC分类号： B01J31/2243 , B01J31/2226 , B01J2231/343 , B01J2531/0258 , B01J2531/0266 , B01J2531/46 , C07F7/003 , Y10S524/923
摘要： The present invention relates to a titanium compound produced from a reaction mixture of a titanium tetraalkoxide compound with water and an optically active ligand represented by the following general formula (1), or a titanium oxoalkoxide compound and an optically active ligand represented by the following general formula (1), wherein, in the formula, R2, R3 and R4 independently represent a hydrogen atom, an alkyl group or the like, and A* represents a hydrocarbon-containing group with three or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for producing optically active cyanohydrins which is characterized by reacting a carbonyl compound with a cyanating agent in the presence of such a titanium compound.
摘要翻译： 本发明涉及由四烷氧基钛化合物与水的反应混合物和由以下通式（1）表示的光学活性配位体制得的钛化合物或由以下通式表示的光学活性配位体 式（1）其中，式中，R 2，R 3和R 4分别表示氢原子，烷基等，A *表示具有3个以上具有不对称碳原子的碳原子的含烃基团， 轴向不对称。 本发明还涉及一种制备光学活性氰醇的方法，其特征在于在这种钛化合物的存在下使羰基化合物与氰化剂反应。
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公开(公告)号：US08563786B2
公开(公告)日：2013-10-22
申请号：US13258735
申请日：2010-03-26
申请人： Manabu Wadamoto , Kazuhiko Yoshinaga , Takushi Nagata , Seayad Abdul Majeed , Ramalingam Balamurugan , Chai Christina L. L.
发明人： Manabu Wadamoto , Kazuhiko Yoshinaga , Takushi Nagata , Seayad Abdul Majeed , Ramalingam Balamurugan , Chai Christina L. L.
IPC分类号： C07C27/18
CPC分类号： C07B53/00 , C07B2200/07 , C07C29/40 , C07C41/30 , C07C2601/14 , C07D213/30 , C07D307/42 , C07C33/46 , C07C33/18 , C07C33/24 , C07C43/23 , C07C33/28 , C07C33/34 , C07C33/20
摘要： Disclosed is a method for producing an optically active alcohol including reacting a titanium compound, an aromatic magnesium compound and a carbonyl compound in the presence of an optically active biphenol compound having a predetermined structure and an ether compound having a predetermined structure.
摘要翻译： 公开了一种光学活性醇的制造方法，其包括在具有预定结构的光学活性联苯酚化合物和具有预定结构的醚化合物的存在下使钛化合物，芳族镁化合物和羰基化合物反应。
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公开(公告)号：US20110319629A1
公开(公告)日：2011-12-29
申请号：US13201053
申请日：2010-02-11
申请人： Abdul Majeed Seayad , Balamurugam Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga , Manabu Wadamoto
发明人： Abdul Majeed Seayad , Balamurugam Ramalingam , Christina Chai , Takushi Nagata , Kazuhiko Yoshinaga , Manabu Wadamoto
IPC分类号： C07D213/57 , C07D333/50 , C07D307/02 , C07F7/28 , C07C253/00
CPC分类号： B01J31/1805 , B01J31/2265 , B01J2231/341 , B01J2531/46 , C07B43/08
摘要： The present invention relates to titanium catalysts for synthesis reactions produced by bringing a reaction mixture comprising a titanium alkoxide and a ligand in contact with water, wherein the ligand is represented by the general formula (e): wherein R1, R2, R3, and R4 are independently a hydrogen atom, an alkyl group, or the like, and (A) represents a group with two or more carbon atoms. The titanium catalysts may be isolated in solid form and may be stored. The invention further relates to a process for cyanation of imines, wherein the process comprises reacting an imine with a cyanating agent in the presence of the titanium catalyst.
摘要翻译： 本发明涉及通过使包含钛醇盐和配体与水接触的反应混合物而制备的合成反应的钛催化剂，其中配体由通式（e）表示：其中R1，R2，R3和R4 独立地为氢原子，烷基等，（A）表示具有2个以上碳原子的基团。 钛催化剂可以以固体形式分离并且可以被储存。 本发明还涉及一种氰化氰胺的方法，其中该方法包括在钛催化剂存在下使亚胺与氰化剂反应。
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9.发明申请公开(公告)号：US20070265463A1
公开(公告)日：2007-11-15
申请号：US11665346
申请日：2005-10-06
IPC分类号： C07C255/00
CPC分类号： B01J31/2243 , B01J31/2226 , B01J2231/343 , B01J2531/0258 , B01J2531/0266 , B01J2531/46 , C07F7/003 , Y10S524/923
摘要： The present invention relates to a titanium compound produced from a reaction mixture of a titanium tetraalkoxide compound with water and an optically active ligand represented by the following general formula (1), or a titanium oxoalkoxide compound and an optically active ligand represented by the following general formula (1), wherein, in the formula, R2, R3 and R4 independently represent a hydrogen atom, an alkyl group or the like, and A* represents a hydrocarbon-containing group with three or more carbon atoms having an asymmetric carbon atom or axial asymmetry. The invention further relates to a process for producing optically active cyanohydrins which is characterized by reacting a carbonyl compound with a cyanating agent in the presence of such a titanium compound.
摘要翻译： 本发明涉及由四烷氧基钛化合物与水的反应混合物和由以下通式（1）表示的光学活性配位体制得的钛化合物或由以下通式表示的光学活性配位体 式（1）其中，在该式中，R 2，R 3和R 4独立地表示氢原子，烷基或 A *表示具有三个以上具有不对称碳原子或轴对称性的碳原子的含烃基团。 本发明还涉及一种制备光学活性氰醇的方法，其特征在于在这种钛化合物的存在下使羰基化合物与氰化剂反应。
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