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    Polymer having bis(diphenylphosphino)binaphthyl groups
    3.
    发明授权
    Polymer having bis(diphenylphosphino)binaphthyl groups 有权
    具有双（二苯基膦基）联萘基的聚合物

    公开(公告)号：US09006484B2

    公开(公告)日：2015-04-14

    申请号：US12376729

    申请日：2007-03-12

    Applicant: Toyoshi Shimada ,  Naomi Takenaka ,  Gakuto Goshima ,  Hiroyuki Hosoi

    Inventor： Toyoshi Shimada ,  Naomi Takenaka ,  Gakuto Goshima ,  Hiroyuki Hosoi

    IPC: C07C55/00 ,  C08G63/00 ,  B01J31/24 ,  C07C45/69 ,  C07F9/50 ,  B01J31/16 ,  C07B53/00 ,  C08F222/10 ,  C08G61/12 ,  C08G63/692

    CPC classification number: C07F9/5027 ,  B01J31/1658 ,  B01J31/2452 ,  B01J2231/641 ,  B01J2231/643 ,  B01J2531/0266 ,  B01J2531/822 ,  C07B53/00 ,  C07C45/69 ,  C08F222/1006 ,  C08G61/12 ,  C08G63/00 ,  C08G63/6924 ,  C08G2261/344 ,  C08G2261/413 ,  C07C49/657

    Abstract: A polymer having bis(diphenylphosphino)binaphthyl groups that can be used as a catalyst for an addition reaction, especially an asymmetric 1,4-addition reaction, or a reduction reaction, especially an asymmetric reduction reaction, and that can be easily recovered and recycled. The polymer having the bis(diphenylphosphino)binaphthyl groups is one resulting from repetition of a racemic or optically active 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl compound substituted at 5-position thereof with an unsaturated terminal of one (meth)acryloyl group of a compound having multiple (meth)acryloyl groups, that another 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl compound of a next unit is substituted at 5′-position thereof with an unsaturated terminal of another (meth)acryloyl group of the compound having multiple (meth)acryloyl groups so as to have a molecular weight of 1500 to 10000. The reduction catalyst comprises this polymer and a transition metal.

    Abstract translation: 具有双（二苯基膦基）联萘基的聚合物，其可用作加成反应的催化剂，特别是不对称的1,4-加成反应或还原反应，特别是不对称还原反应，并且可以容易地回收和回收 。 具有双（二苯基膦基）联萘基的聚合物是由在5-位取代的外消旋或光学活性的2,2'-双（二苯基膦基）-1,1'-联萘化合物与不饱和末端一个 具有多个（甲基）丙烯酰基的化合物的（甲基）丙烯酰基，下一个单元的另一个2,2'-双（二苯基膦基）-1,1'-联萘化合物在其5'-位被不饱和 具有多个（甲基）丙烯酰基的化合物的另一（甲基）丙烯酰基的末端，以具有1500至10000的分子量。还原催化剂包含该聚合物和过渡金属。

    Method for producing optically active fluorinated oxetane
    6.
    发明授权
    Method for producing optically active fluorinated oxetane 有权
    光学活性氟代氧杂环丁烷的制造方法

    公开(公告)号：US08809557B2

    公开(公告)日：2014-08-19

    申请号：US13201171

    申请日：2010-02-22

    Applicant: Koichi Mikami ,  Kohsuke Aikawa ,  Junpei Aida ,  Akihiro Ishii ,  Misugi Kato ,  Takashi Masuda

    Inventor： Koichi Mikami ,  Kohsuke Aikawa ,  Junpei Aida ,  Akihiro Ishii ,  Misugi Kato ,  Takashi Masuda

    IPC: C07D305/04

    CPC classification number: C07D305/04 ,  B01J31/223 ,  B01J31/2409 ,  B01J2231/32 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2531/824 ,  C07B53/00 ,  C07D305/08

    Abstract: Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity.

    Abstract translation: 公开了通过氟化α-酮酯与酰基烯基醚在过渡金属配合物与光学活性配体的存在下反应，制备可以是重要的药用或农业中间体的光学活性氟化氧杂环丁烷的方法。 该方法利用催化不对称合成方法，不需要化学计量的手性源。 因此，可以显着地减少不对称催化剂的使用量，特别是当在高浓度的底物（使用少量的反应溶剂）下进行反应时，或者在没有反应溶剂的情况下 条件）。 此外，可以高产率和非常高的光学纯度获得目标光学活性氟化氧杂环丁烷。 该产品几乎没有难以分离的杂质，显示出高的化学纯度。

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