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公开(公告)号:US20120219552A1
公开(公告)日:2012-08-30
申请号:US13502347
申请日:2010-10-18
申请人: Kazuhiro Irie , Kazuma Murakami , Yuichi Masuda , Takahiko Shimizu , Takuji Shirasawa , Tsutomu Seito
发明人: Kazuhiro Irie , Kazuma Murakami , Yuichi Masuda , Takahiko Shimizu , Takuji Shirasawa , Tsutomu Seito
IPC分类号: A61K39/395 , A61P25/28 , G01N33/566 , C07K16/00
CPC分类号: C07K16/18 , C07K2317/33 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: Provided is a therapeutic method exclusively targeting an amyloid β protein (Aβ) having a specific turn structure of Aβ. Specifically provided is an antibody which specifically recognizes an amyloid β having a turn structure at amino acids positions 22 and 23. Also provided are a medicinal composition comprising, as the active ingredient, an antibody specifically recognizing a toxic conformer of amyloid β, an assay kit for a toxic conformer of amyloid β, a diagnostic for Alzheimer's disease, etc.
摘要翻译: 提供专门针对淀粉样蛋白的治疗方法; 具有A&bgr的特定转向结构的蛋白质(A&bgr)。 具体提供的是特异性识别淀粉样蛋白和抗原的抗体; 在氨基酸位置22和23处具有转向结构。还提供了药物组合物,其包含作为活性成分的特异性识别淀粉样蛋白和bgr的毒性构象异构体的抗体;用于淀粉样蛋白的有毒构象异构体的测定试剂盒 诊断阿尔茨海默病等
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公开(公告)号:US08710193B2
公开(公告)日:2014-04-29
申请号:US13502347
申请日:2010-10-18
申请人: Kazuhiro Irie , Kazuma Murakami , Yuichi Masuda , Takahiko Shimizu , Takuji Shirasawa , Tsutomu Seito
发明人: Kazuhiro Irie , Kazuma Murakami , Yuichi Masuda , Takahiko Shimizu , Takuji Shirasawa , Tsutomu Seito
IPC分类号: C07K16/18 , C07K16/46 , A61B5/145 , A61K39/395
CPC分类号: C07K16/18 , C07K2317/33 , C07K2317/76 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要: Provided is a therapeutic method exclusively targeting an amyloid β protein (Aβ) having a specific turn structure of Aβ. Specifically provided is an antibody which specifically recognizes an amyloid β having a turn structure at amino acids positions 22 and 23. Also provided are a medicinal composition comprising, as the active ingredient, an antibody specifically recognizing a toxic conformer of amyloid β, an assay kit for a toxic conformer of amyloid β, a diagnostic for Alzheimer's disease, etc.
摘要翻译: 提供专门针对淀粉样蛋白的治疗方法; 具有A&bgr的特定转向结构的蛋白质(A&bgr)。 具体提供的是特异性识别淀粉样蛋白和抗原的抗体; 在氨基酸位置22和23处具有转向结构。还提供了药物组合物,其包含作为活性成分的特异性识别淀粉样蛋白和bgr的毒性构象异构体的抗体;用于淀粉样蛋白的有毒构象异构体的测定试剂盒 诊断阿尔茨海默病等
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