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公开(公告)号:US20090280094A1
公开(公告)日:2009-11-12
申请号:US12303669
申请日:2007-06-07
申请人: Toshio Matsumoto , Tetsuya Kitagawa , Masahiro Abe , Masashi Akaike , Kazunari Nagayoshi , Kaname Yamamoto , Masato Higuchi
发明人: Toshio Matsumoto , Tetsuya Kitagawa , Masahiro Abe , Masashi Akaike , Kazunari Nagayoshi , Kaname Yamamoto , Masato Higuchi
CPC分类号: A61K38/1816 , A61K35/28 , C12N5/0634 , C12N2501/14
摘要: Disclosed is a method for stimulating revascularization in a subject comprising the steps of: (a) administering erythropoietin to the subject; (b) collecting peripheral blood mononuclear cells from the subject; and (c) administering the collected peripheral blood mononuclear cells to a target site of the subject. Peripheral blood mononuclear cells, and particularly CD34-positive cells, are mobilized into the peripheral blood of a subject by the administration of erythropoietin to the subject. The method of the present invention is useful for the treatment of ischemic diseases, such as peripheral vascular disorder.
摘要翻译: 公开了一种刺激受试者血运重建的方法,包括以下步骤:(a)向受试者施用促红细胞生成素; (b)从受试者收集外周血单核细胞; 和(c)将收集的外周血单核细胞给予受试者的靶位点。 外周血单核细胞,特别是CD34阳性细胞通过向受试者施用促红细胞生成素而被动员到受试者的外周血中。 本发明的方法可用于治疗缺血性疾病,例如外周血管病变。