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公开(公告)号：US08067586B2
公开(公告)日：2011-11-29
申请号：US12688272
申请日：2010-01-15
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D413/00
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要翻译： 本发明提供了可用作磷脂酰肌醇3激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，其提供了具有优异的PI3K抑制活性和癌细胞生长的新型双环或三环稠合杂芳基衍生物或其盐 抑制活性。
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公开(公告)号：US20100137584A1
公开(公告)日：2010-06-03
申请号：US12688272
申请日：2010-01-15
申请人： Masahiko HAYAKAWA , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko HAYAKAWA , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D487/04
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要翻译： 本发明提供了可用作磷脂酰肌醇3激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，其提供了具有优异的PI3K抑制活性和癌细胞生长的新型双环或三环稠合杂芳基衍生物或其盐 抑制活性。
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公开(公告)号：US07173029B2
公开(公告)日：2007-02-06
申请号：US11250782
申请日：2005-10-14
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D495/04 , A61K31/519 , C07D487/04
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要翻译： 本发明提供了可用作磷脂酰肌醇3激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，其提供了具有优异的PI3K抑制活性和癌细胞生长的新型双环或三环稠合杂芳基衍生物或其盐 抑制活性。
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公开(公告)号：US20060058321A1
公开(公告)日：2006-03-16
申请号：US11250782
申请日：2005-10-14
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： A61K31/519 , C07D491/02 , C07D498/02 , C07D498/14
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要翻译： 本发明提供了可用作磷脂酰肌醇3激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，其提供了具有优异的PI3K抑制活性和癌细胞生长的新型双环或三环稠合杂芳基衍生物或其盐 抑制活性。
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公开(公告)号：US20050014771A1
公开(公告)日：2005-01-20
申请号：US10918094
申请日：2004-08-13
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/04 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
摘要翻译： 本发明提供了可用作磷脂酰肌醇3激酶（PI3K）抑制剂和抗肿瘤剂的药物组合物，其提供了具有优异的PI3K抑制活性和癌细胞生长的新型双环或三环稠合杂芳基衍生物或其盐 抑制活性。
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公开(公告)号：US06608056B1
公开(公告)日：2003-08-19
申请号：US10243416
申请日：2002-09-13
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D48704
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
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公开(公告)号：US20100137585A1
公开(公告)日：2010-06-03
申请号：US12688273
申请日：2010-01-15
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D487/04 , C07D491/048 , C07D495/04
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
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公开(公告)号：US06403588B1
公开(公告)日：2002-06-11
申请号：US09843610
申请日：2001-04-26
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Ken-Ichi Kawaguchi , Koyo Matsuda , Noriko Ishikawa , Tomonobu Koizumi , Mayumi Yamano , Minoru Okada , Mitsuaki Ohta
IPC分类号： A61K31435
CPC分类号： C07D471/04 , A61K31/435 , C07D487/04
摘要： The present invention relates to novel compounds having a phosphatidylinositol 3 kinase (PI3K) inhibiting activity which are useful as medicaments, more particularly as antitumor agent. Novel 3-(imidazo[1,2-a]pyridin-3-yl) derivatives or salts thereof exhibit an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity, and are thus useful as medicaments, especially as PI3K inhibitors and antitumor agents.
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公开(公告)号：US06608053B2
公开(公告)日：2003-08-19
申请号：US09843615
申请日：2001-04-26
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： C07D41304
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
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公开(公告)号：US20070037805A1
公开(公告)日：2007-02-15
申请号：US11544144
申请日：2006-10-06
申请人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
发明人： Masahiko Hayakawa , Hiroyuki Kaizawa , Hiroyuki Moritomo , Ken-Ichi Kawaguchi , Tomonobu Koizumi , Mayumi Yamano , Koyo Matsuda , Minoru Okada , Mitsuaki Ohta
IPC分类号： A61K31/5377
CPC分类号： C07D471/04 , A61K31/00 , A61K31/517 , A61K31/519 , A61K31/5377 , C07D471/14 , C07D491/04 , C07D491/14 , C07D495/04 , C07D495/14
摘要： The present invention provides a pharmaceutical composition which is useful as a phosphatidylinositol 3 kinase (PI3K) inhibitor and an antitumor agent, and it provides a novel bicyclic or tricyclic fused heteroaryl derivative or a salt thereof which possesses an excellent PI3K inhibiting activity and cancer cell growth inhibiting activity.
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