公开(公告)号：US20130309203A1

公开(公告)日：2013-11-21

申请号：US13876916

申请日：2011-09-29

申请人： Ken-ichiro Kosai

发明人： Ken-ichiro Kosai

IPC分类号： C12N15/86

摘要： Disclosed is a vector, preferably a viral vector, containing a treatment factor and/or a nucleic acid encoding a cytotoxic factor under control of an Aurora kinase promoter. Also disclosed is a virus vector in which the promoter of a nucleic acid encoding a factor necessary to the replication or assembly of at least one virus is substituted by the Aurora kinase promoter. Also disclosed are a disease treatment agent, in particular a cancer treatment agent, which contains the aforementioned vector, and a clinical diagnostic agent, in particular a cancer diagnostic agent, which contains the vector containing the Aurora kinase promoter.

摘要翻译： 公开了一种载体，优选病毒载体，其含有治疗因子和/或编码在极光激酶启动子控制下的细胞毒性因子的核酸。 还公开了病毒载体，其中编码至少一种病毒的复制或组装必需的因子的核酸的启动子被Aurora激酶启动子取代。 还公开了含有上述载体的疾病治疗剂，特别是癌症治疗剂，以及包含含有极光激酶启动子的载体的临床诊断剂，特别是癌症诊断剂。

公开(公告)号：US10905742B2

公开(公告)日：2021-02-02

申请号：US11992728

申请日：2006-09-28

申请人： Ken-ichiro Kosai ,  Cin Khai Ngin ,  Tomoyuki Takahashi

发明人： Ken-ichiro Kosai ,  Cin Khai Ngin ,  Tomoyuki Takahashi

IPC分类号： C12N15/86 ,  A61K38/18 ,  A61K48/00

摘要： The present invention provides an agent for protecting the liver and/or promoting liver regeneration, which contains a heparin-binding EGF-like growth factor-like growth factor (HB-EGF) or a partial peptide thereof, or a nucleic acid that encodes same, and an agent for the prophylaxis or treatment of liver diseases. The present invention further provides a method for producing a cell for liver protection and/or promoting liver regeneration, and for the prophylaxis/treatment of a liver disease, which includes introducing a nucleic acid that encodes HB-EGF or a partial peptide thereof into a cell collected from an animal.

公开(公告)号：US10738324B2

公开(公告)日：2020-08-11

申请号：US13876916

申请日：2011-09-29

申请人： Ken-ichiro Kosai

发明人： Ken-ichiro Kosai

IPC分类号： C12N15/86 ,  C12N7/00 ,  A61K35/76 ,  C12N9/12

摘要： Disclosed is a vector, preferably a viral vector, containing a treatment factor and/or a nucleic acid encoding a cytotoxic factor under control of an Aurora kinase promoter. Also disclosed is a virus vector in which the promoter of a nucleic acid encoding a factor necessary to the replication or assembly of at least one virus is substituted by the Aurora kinase promoter. Also disclosed are a disease treatment agent, in particular a cancer treatment agent, which contains the aforementioned vector, and a clinical diagnostic agent, in particular a cancer diagnostic agent, which contains the vector containing the Aurora kinase promoter.

公开(公告)号：US20090130062A1

公开(公告)日：2009-05-21

申请号：US11992728

申请日：2006-09-28

申请人： Ken-ichiro Kosai ,  Cin Khai Ngin ,  Tomoyuki Takahashi

发明人： Ken-ichiro Kosai ,  Cin Khai Ngin ,  Tomoyuki Takahashi

IPC分类号： A61K48/00 ,  A61K31/711 ,  A61K38/18 ,  A61P1/16

CPC分类号： A61K38/1808 ,  A61K48/005 ,  C12N15/86 ,  C12N2710/10332 ,  C12N2710/10343 ,  C12N2710/10371

摘要： The present invention provides an agent for protecting the liver and/or promoting liver regeneration, which contains a heparin-binding EGF-like growth factor-like growth factor (HB-EGF) or a partial peptide thereof, or a nucleic acid that encodes same, and an agent for the prophylaxis or treatment of liver diseases. The present invention further provides a method for producing a cell for liver protection and/or promoting liver regeneration, and for the prophylaxis/treatment of a liver disease, which includes introducing a nucleic acid that encodes HB-EGF or a partial peptide thereof into a cell collected from an animal.

摘要翻译： 本发明提供一种用于保护肝脏和/或促进肝脏再生的药剂，其含有肝素结合的EGF样生长因子样生长因子（HB-EGF）或其部分肽，或编码其的核酸 ，以及预防或治疗肝脏疾病的药剂。 本发明还提供了用于肝保护和/或促进肝再生的细胞的制备方法和用于预防/治疗肝脏疾病的方法，其包括将编码HB-EGF或其部分肽的核酸引入到 从动物收集的细胞。