公开(公告)号：US20080008688A1

公开(公告)日：2008-01-10

申请号：US11421301

申请日：2006-05-31

申请人： Kenneth Stokes ,  Josee Morissette

发明人： Kenneth Stokes ,  Josee Morissette

IPC分类号： A61K48/00

CPC分类号： A61K48/0075 ,  A61K38/1709 ,  A61K48/00 ,  A61M5/3291 ,  A61M2025/0089 ,  C07K14/705

摘要： The present invention provides delivery systems for and methods of delivering conduction protein genetic material to cardiac cells in localized areas of the heart to improve the conductance therein. More specifically, there is provided a system and method for delivering connexin proteins or nucleic acid molecules encoding connexin proteins to a site in the heart which has been determined by mapping procedures to have a conduction disturbance. For cases where conduction is impaired, selected genetic material is delivered to cells around the disturbance area, in order to enhance overall conductivity patterns; in other cases, genetic material is selected to slow conduction in affected areas, so as to prevent, e.g., brady-tachy syndrome.

摘要翻译： 本发明提供了将传导蛋白遗传物质递送到心脏局部区域的心脏细胞的递送系统和方法，以改善其中的电导。 更具体地，提供了一种用于将连接蛋白或编码连接蛋白的核酸分子递送至心脏部位的系统和方法，其通过测绘程序确定具有传导障碍。 对于传导受损的情况，选择的遗传物质被传递到扰动区周围的细胞，以增强整体的导电性; 在其他情况下，选择遗传物质以缓解受影响区域的传导，以便防止例如缓慢型综合征。

公开(公告)号：US06350949B1

公开(公告)日：2002-02-26

申请号：US09602309

申请日：2000-06-23

申请人： Kenneth Stokes Boyd

发明人： Kenneth Stokes Boyd

IPC分类号： H05K506

CPC分类号： B60R16/0238 ,  H05K7/026

摘要： An environmentally sealed power distribution module is disclosed having a hybrid peripheral seal disposed around a power distribution panel and within an interface between a top housing and a base housing. The peripheral seal is comprised of a traditional o-ring type seal having an open segment and a gel pad type seal located within the open segment, thereby completing the peripheral seal. Plate-like power distribution bus bars are reliably sealed by the gel pad type seal as the bus bars exit the power distribution module. A sealed releasable cover is provided to access fuses and other electrical components of the power distribution module.

摘要翻译： 公开了一种环境密封的配电模块，其具有设置在配电盘周围并且在顶部壳体和基座壳体之间的界面内的混合外围密封件。 外围密封件由传统的O型圈密封件组成，该密封件具有位于开口段内的开口段和凝胶垫型密封件，从而完成周边密封。 当母线退出配电模块时，板状配电汇流条由凝胶垫型密封件可靠地密封。 提供密封的可释放盖以便接近配电模块的保险丝和其他电气部件。

公开(公告)号：US5265608A

公开(公告)日：1993-11-30

申请号：US802953

申请日：1991-12-05

申请人： Philip Lee ,  Kenneth Stokes ,  Michael Colson

发明人： Philip Lee ,  Kenneth Stokes ,  Michael Colson

IPC分类号： A61N1/05 ,  A61B5/04

CPC分类号： A61N1/0556

摘要： An improved electrode for establishing electrical contact with a nerve of a patient. This electrical contact may be used to sense neural activity on the nerve or to artificially stimulate it to perform various medical treatments. One embodiment of the electrode has an outer cuff of an insulating material which is sutured around the nerve to be contacted. A drug impregnated layer of material is positioned inside of the outer cuff. This material is a polymeric matrix which permits the drug to leach out at a predetermined rate. The drug is preferably a glucocortico steroid such as dexamethasone sodium phosphate. The actual electrical contact is produced by metallic foil which is positioned on the surface of the drug impregnated layer of material which is located inside of the cuff. A second embodiment employs a half cuff which is held in contact with the nerve tissue by being sutured to muscle tissue. The insulative substrate of the half cuff is a drug impregnated polymeric matrix. The electrode is a metallic disc, preferably round or oval in shape, which is recessed into the insulative substrate. An insulated lead electrically couples the metallic foil or metallic disc to an electronic circuit located remote from the nerve. The leaching out of the drug serves to control inflammation, irritation and swelling, and stabilizes the impedance and threshold of the nerve/electrode interface.

摘要翻译： 用于与患者的神经建立电接触的改进的电极。 该电接触可用于感测神经上的神经活动或人为地刺激其进行各种医学治疗。 电极的一个实施例具有绝缘材料的外箍，其被缝合在要接触的神经周围。 药物浸渍的材料层位于外箍内侧。 该材料是允许药物以预定速率浸出的聚合物基质。 该药物优选为葡萄糖皮质类固醇，例如地塞米松磷酸钠。 实际的电接触由金属箔制成，该金属箔位于位于袖带内部的药物浸渍材料层的表面上。 第二实施例采用通过缝合到肌肉组织而与神经组织保持接触的半箍。 半箍的绝缘底物是药物浸渍的聚合物基质。 电极是金属盘，优选为圆形或椭圆形，其凹入绝缘基底。 绝缘引线将金属箔或金属盘电耦合到远离神经的电子电路。 药物中的浸出物用于控制炎症，刺激和肿胀，稳定神经/电极界面的阻抗和阈值。

公开(公告)号：US5092332A

公开(公告)日：1992-03-03

申请号：US483455

申请日：1990-02-22

申请人： Philip Lee ,  Kenneth Stokes ,  James Gates ,  Gary Johnson

发明人： Philip Lee ,  Kenneth Stokes ,  James Gates ,  Gary Johnson

IPC分类号： A61B5/0408 ,  A61B5/0478 ,  A61B5/0492 ,  A61N1/05 ,  A61N1/30

CPC分类号： A61N1/0556

摘要： An improved electrode for establishing electrical contact with a nerve of a patient. This electrical contact may be used to sense neural activity on the nerve or to artificially stimulate it to perform various medical treatments. The electrode has an outer cuff of an insulating material which is sutured around the nerve to be contacted. A drug impregnated layer of material is positioned inside of the outer cuff. This material is a polymeric matrix which permits the drug to leach out at a predetermined rate. The drug is a steroid such as dexamethasone sodium phosphate. The actual electrical contact is produced by metallic foil which is positioned on the surface of the drug impregnated layer of material which is located inside of the cuff. An insulated lead electrically couples the metallic foil to an electronic circuit located remote from the nerve. The leaching out of the drug serves to control irritation, swelling, and impedance of the nerve/electrode interface.

摘要翻译： 用于与患者的神经建立电接触的改进的电极。 该电接触可用于感测神经上的神经活动或人为地刺激其进行各种医学治疗。 电极具有绝缘材料的外套，缝合在要接触的神经周围。 药物浸渍的材料层位于外箍内侧。 该材料是允许药物以预定速率浸出的聚合物基质。 该药物是类固醇，如地塞米松磷酸钠。 实际的电接触由金属箔制成，该金属箔位于位于袖带内部的药物浸渍材料层的表面上。 绝缘引线将金属箔电耦合到远离神经的电子电路。 药物中的浸出物用于控制神经/电极界面的刺激，肿胀和阻抗。