公开(公告)号：US20110257207A1

公开(公告)日：2011-10-20

申请号：US13105957

申请日：2011-05-12

Applicant: Alexander BACKES ,  Joachim VOGT ,  Peter AMON ,  Igor IVANOV ,  Stefan HANNUS ,  Matthias BORGMANN ,  Kerrin HANSEN ,  Rebecca CASAUBON ,  Chase SMITH ,  Krishna MURTHI ,  Arthur KLUGE ,  Andreas SCHOOP ,  Lars NEUMANN ,  Jan EICKHOFF

Inventor： Alexander BACKES ,  Joachim VOGT ,  Peter AMON ,  Igor IVANOV ,  Stefan HANNUS ,  Matthias BORGMANN ,  Kerrin HANSEN ,  Rebecca CASAUBON ,  Chase SMITH ,  Krishna MURTHI ,  Arthur KLUGE ,  Andreas SCHOOP ,  Lars NEUMANN ,  Jan EICKHOFF

IPC: A61K31/519 ,  A61P35/00 ,  C07D471/04

CPC classification number: C07D471/04

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是抑制剂或激酶如Raf，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US08232283B2

公开(公告)日：2012-07-31

申请号：US13105957

申请日：2011-05-12

Applicant: Andreas Schoop ,  Alexander Backes ,  Joachim Vogt ,  Lars Neumann ,  Jan Eickhoff ,  Stefan Hannus ,  Kerrin Hansen ,  Peter Amon ,  Igor Ivanov ,  Matthias Borgmann ,  Chase Smith ,  Arthur F. Kluge ,  Krishan Murthi ,  Rebecca Casaubon

Inventor： Andreas Schoop ,  Alexander Backes ,  Joachim Vogt ,  Lars Neumann ,  Jan Eickhoff ,  Stefan Hannus ,  Kerrin Hansen ,  Peter Amon ,  Igor Ivanov ,  Matthias Borgmann ,  Chase Smith ,  Arthur F. Kluge ,  Krishan Murthi ,  Rebecca Casaubon

IPC: C07D471/04 ,  A61K31/505 ,  A61P35/00

CPC classification number: C07D471/04

Abstract: The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are inhibitors or kinases such as Raf, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

Abstract translation: 本发明提供吡啶并[2,3-d]嘧啶-7-酮的衍生物。 这些化合物是抑制剂或激酶如Raf，包括显示抗增殖活性的化合物，包括抗肿瘤细胞，并且可用于治疗包括癌症在内的疾病。

公开(公告)号：US20120021942A1

公开(公告)日：2012-01-26

申请号：US13146930

申请日：2010-02-01

Applicant: Kerrin Hansen ,  Stefan Hannus ,  Frank Becker

Inventor： Kerrin Hansen ,  Stefan Hannus ,  Frank Becker

IPC: C40B30/04 ,  G01N33/566

CPC classification number: G01N21/6428 ,  G01N21/6408 ,  G01N21/6458 ,  G01N33/582 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6441 ,  G01N2021/6482

Abstract: The present invention relates to the determination of interaction parameters of at least two analytes in cellular lysates, wherein at least one competitive agent is optionally further present.

Abstract translation: 本发明涉及确定细胞裂解物中至少两种分析物的相互作用参数，其中任选地还可以存在至少一种竞争性试剂。