-
公开(公告)号:US07626011B2
公开(公告)日:2009-12-01
申请号:US11802989
申请日:2007-05-29
IPC分类号: C07H21/04
CPC分类号: C07K16/3007 , A61K2039/505 , C07K16/00 , C07K16/005 , C07K2317/24 , C07K2317/565 , C07K2317/622
摘要: The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity antibodies against carcinoembryonic antigen (CEA), especially the antibody we have termed sm3E, which is derived from the scFv antibody MFE-23. Such antibodies have the potential for improved therapeutic efficacy.
摘要翻译: 本发明涉及抗肿瘤表面抗原的改进抗体及其在治疗肿瘤中的用途。 特别令人感兴趣的是高度稳定的,人源化的,高亲和力的针对癌胚抗原(CEA)的抗体,特别是源自scFv抗体MFE-23的称为sm3E的抗体。 这样的抗体具有改善治疗功效的潜力。
-
公开(公告)号:US07232888B2
公开(公告)日:2007-06-19
申请号:US10609671
申请日:2003-07-01
IPC分类号: C07K16/00
CPC分类号: C07K16/3007 , A61K2039/505 , C07K16/00 , C07K16/005 , C07K2317/24 , C07K2317/565 , C07K2317/622
摘要: The present invention relates to improved antibodies against tumor surface antigens and their use in the treatment of tumors. Of particular interest are highly stable, humanized, high affinity antibodies against carcinoembryonic antigen (CEA), especially the antibody we have termed sm3E, which is derived from the scFv antibody MFE-23. Such antibodies have the potential for improved therapeutic efficacy.
摘要翻译: 本发明涉及抗肿瘤表面抗原的改进抗体及其在治疗肿瘤中的用途。 特别令人感兴趣的是高度稳定的,人源化的,高亲和力的针对癌胚抗原(CEA)的抗体,特别是源自scFv抗体MFE-23的称为sm3E的抗体。 这样的抗体具有改善治疗功效的潜力。
-