公开(公告)号：US07291712B2

公开(公告)日：2007-11-06

申请号：US10015967

申请日：2001-12-07

申请人： Dan L. Eaton ,  Dorothy French ,  J. Christopher Grimaldi ,  Kenneth J. Hillan ,  Maria Teresa Pisabaro ,  Kerstin N. Schmidt ,  Victoria Smith ,  Daniel Tumas ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

发明人： Dan L. Eaton ,  Dorothy French ,  J. Christopher Grimaldi ,  Kenneth J. Hillan ,  Maria Teresa Pisabaro ,  Kerstin N. Schmidt ,  Victoria Smith ,  Daniel Tumas ,  Richard Vandlen ,  Colin K. Watanabe ,  P. Mickey Williams ,  William I. Wood

IPC分类号： C07K14/00

CPC分类号： C07K14/52 ,  C07K14/47 ,  C07K14/5421 ,  C07K14/705 ,  C12Q1/6883 ,  C12Q2600/136 ,  C12Q2600/158 ,  G01N33/564 ,  G01N33/6863 ,  G01N33/6869 ,  G01N33/6893

摘要： The present invention is directed to novel polypeptides having structural homology to IL-8 and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treatment and diagnosis of inflammatory diseases.

摘要翻译： 本发明涉及与IL-8和编码那些多肽的核酸分子具有结构同源性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文进一步提供了治疗和诊断炎性疾病的方法。