公开(公告)号：US20230372492A1

公开(公告)日：2023-11-23

申请号：US18247049

申请日：2021-09-29

申请人： Joo Youn PARK ,  Keun Seok SEO ,  Seung Seo LEE

发明人： Joo Youn PARK ,  Keun Seok SEO ,  Seung Seo LEE

IPC分类号： A61K47/54 ,  A61P31/04

CPC分类号： A61K47/549 ,  A61P31/04

摘要： A drug conjugate, composition, and method for delivering active antimicrobials based on existing antibiotics through a hexose phosphate transporter (UhpT) by conjugating the antimicrobials with non-metabolizable hexose phosphates. Methods of co-administering antibiotics with non-metabolizable hexose phosphates as antimicrobials are also disclosed. Non-metabolizable hexose phosphates can constitutively and strongly induce expression of UhpT which significantly improves the efficacy and/or antimicrobial spectrum of antibiotics. This drug conjugate, composition and method will permit reuse of many FDA approved antibiotics that have been abandoned or fallen into disuse due to their current low efficacy and/or resistance to these antibiotics by pathogens.

公开(公告)号：US20190017045A1

公开(公告)日：2019-01-17

申请号：US16034089

申请日：2018-07-12

申请人： Keun Seok Seo ,  Joo Youn Park

发明人： Keun Seok Seo ,  Joo Youn Park

IPC分类号： C12N15/11 ,  C12N9/22 ,  A61K9/00 ,  A01N63/02 ,  C12N15/66 ,  C12N15/74 ,  A61K38/46 ,  A61K31/7088

摘要： A method and composition for the production of sequence specific antimicrobials capable of overcoming inefficient delivery, narrow host range, and potential transfer of virulence genes by generalized transduction of phage-based delivery systems by integrating CRISPR/Cas9 system in the phage genome, removing major virulence genes from host chromosome, and expanding host specificity of phage by complementing tail fiber protein which significantly improves the efficacy and safety of CRISPR/Cas9 antimicrobials as alternative therapeutics. The method and composition provide an efficacious and safe CRISPR/Cas9 antimicrobial, broadly applicable to MRSA.