公开(公告)号：US08318762B2

公开(公告)日：2012-11-27

申请号：US12934375

申请日：2009-05-18

Applicant: Jeffrey W. Corbett ,  Richard Elliott ,  Kevin Freeman-Cook ,  David A. Griffith ,  Dennis P. Phillion

Inventor： Jeffrey W. Corbett ,  Richard Elliott ,  Kevin Freeman-Cook ,  David A. Griffith ,  Dennis P. Phillion

IPC: C07D491/107 ,  A61K31/436 ,  A61K31/438

CPC classification number: C07D491/20

Abstract: The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.

Abstract translation: 本发明提供式（1）的化合物或所述化合物的药学上可接受的盐，其中R 1，R 2和R 3如本文所述; 其药物组合物; 以及其在治疗通过抑制动物体内的乙酰辅酶A羧化酶调节的疾病，病症或病症中的用途。

公开(公告)号：US20080051419A1

公开(公告)日：2008-02-28

申请号：US11780654

申请日：2007-07-20

Applicant: Matthew Corbett ,  Kevin Freeman-Cook ,  Goss Kauffman ,  Blaise Lippa ,  Michael Luzzio ,  Joel Morris

Inventor： Matthew Corbett ,  Kevin Freeman-Cook ,  Goss Kauffman ,  Blaise Lippa ,  Michael Luzzio ,  Joel Morris

IPC: A61K31/497 ,  A61P35/04 ,  C07D487/02

CPC classification number: C07D487/04 ,  C07D473/34

Abstract: The invention relates to compounds of formula I: or a pharmaceutically acceptable salt thereof, wherein: A is a moiety of formula: and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, D, E, V, W, Y, R1, R2, R5, R6, L, and u are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I to a patient in need thereof, and to compositions for treating such disorders which contain the compounds of formula I. The invention also relates to methods of making the compounds of formula I.

Abstract translation: 本发明涉及式I化合物或其药学上可接受的盐，其中：A是下式的部分：其药学上可接受的盐和溶剂合物，其中X，Z，D，E，V，W，Y，R R 1，R 2，R 5，R 6，L和u如本文所定义。 本发明还涉及通过向有需要的患者施用式I化合物和用于治疗含有式I化合物的这种病症的组合物来治疗哺乳动物异常细胞生长的方法。本发明还涉及制备方法 式I的化合物。

公开(公告)号：US06900201B2

公开(公告)日：2005-05-31

申请号：US10423779

申请日：2003-04-25

Applicant: Mark C. Noe ,  Kevin Freeman-Cook

Inventor： Mark C. Noe ,  Kevin Freeman-Cook

IPC: A61K31/527 ,  A61P1/16 ,  A61P3/00 ,  A61P9/00 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P19/02 ,  A61P25/02 ,  A61P27/02 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/00 ,  A61P37/08 ,  A61P43/00 ,  C07D487/10

CPC classification number: C07D487/10

Abstract: The present invention relates to N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors of the formula wherein ring X is a 5-7 membered heterocyclic ring, and wherein A, Y, B, and G are as defined in the specification; and to pharmaceutical compositions and methods of treating inflammation, cancer and other disorders.

Abstract translation: 本发明涉及下式的N-取代杂芳氧基 - 芳基 - 螺 - 嘧啶-2,4,6-三酮金属蛋白酶抑制剂，其中环X是5-7元杂环，其中A，Y，B和 G如规范中所定义; 以及治疗炎症，癌症和其他疾病的药物组合物和方法。

公开(公告)号：US20110028390A1

公开(公告)日：2011-02-03

申请号：US12934375

申请日：2009-05-18

Applicant: Jeffrey W. Corbett ,  Richard Elliott ,  Kevin Freeman-Cook ,  David A. Griffith ,  Dennis P. Phillion

Inventor： Jeffrey W. Corbett ,  Richard Elliott ,  Kevin Freeman-Cook ,  David A. Griffith ,  Dennis P. Phillion

IPC: A61K38/17 ,  C07D491/20 ,  A61K31/438 ,  A61K31/538 ,  A61K31/55 ,  A61K31/566 ,  A61K38/16 ,  A61K38/22 ,  A61K31/4985 ,  A61K31/4965 ,  A61P3/10 ,  A61P3/04 ,  A61P1/16

CPC classification number: C07D491/20

Abstract: The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.

Abstract translation: 本发明提供式（1）的化合物或所述化合物的药学上可接受的盐，其中R 1，R 2和R 3如本文所述; 其药物组合物; 以及其在治疗通过抑制动物体内的乙酰辅酶A羧化酶调节的疾病，病症或病症中的用途。