公开(公告)号：US20070135495A1

公开(公告)日：2007-06-14

申请号：US10583438

申请日：2004-12-15

申请人： Jae-Sun Kim ,  Jin Choi ,  Je Ryu ,  Nam Lee ,  Jeong-soo Jang ,  Woo Jang ,  Key Um ,  Do Kum

发明人： Jae-Sun Kim ,  Jin Choi ,  Je Ryu ,  Nam Lee ,  Jeong-soo Jang ,  Woo Jang ,  Key Um ,  Do Kum

IPC分类号： C07D211/82 ,  A61K31/455

CPC分类号： C07D211/90

摘要： The present invention relates to an acid salt of amlodipine gentisate and a method of its preparation. More particularly, the present invention relates to a crystalline acid salt of amlodipine gentisate of the following formula 1 prepared by reacting amlodipine and gentisic acid, which is useful for the treatment of cardiovascular diseases and has the advantages of low toxicity, excellent stability, improved pharmaceutical efficacies and long-lasting concentration in blood.

摘要翻译： 本发明涉及一种氨氯地平龙胆酸的酸性盐及其制备方法。 更具体地说，本发明涉及通过使氨氯地平和龙胆酸反应制备的下式1的氨氯地平结晶酸盐，其可用于治疗心血管疾病，并且具有毒性低，稳定性优异的药物 血液中的功效和持久的浓度

公开(公告)号：US20070212408A1

公开(公告)日：2007-09-13

申请号：US11587720

申请日：2005-04-27

申请人： Nam Kim ,  Jin Choi ,  Jae Kim ,  Nam Lee ,  Je Ryu ,  Yong Hwang ,  Yong Oh ,  Dong Min ,  Key Um ,  Wei-Jong Kwak ,  Do Kum

发明人： Nam Kim ,  Jin Choi ,  Jae Kim ,  Nam Lee ,  Je Ryu ,  Yong Hwang ,  Yong Oh ,  Dong Min ,  Key Um ,  Wei-Jong Kwak ,  Do Kum

IPC分类号： A61K31/724 ,  C08B30/18 ,  A61K9/48 ,  A61K9/20

CPC分类号： B82Y5/00 ,  A61K47/6951

摘要： The present invention relates to an inclusion complex containing a benzimidazole derivative with excellent storage stability and a method of its preparation. In particular, the present invention relates to an inclusion complex containing a benzimidazole derivative with improved storage stability and a method of its preparation, where an inclusion complex is manufactured by performing an inclusion reaction by combining a benzimidazole derivative, cyclodextrin and a water-soluble polymer in an aqueous alkali solution in order to be formulated after stabilizing an acid-unstable benzimidazole derivative.

摘要翻译： 本发明涉及包含具有优异储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法。 特别地，本发明涉及包含具有改进的储存稳定性的苯并咪唑衍生物的包合络合物及其制备方法，其中通过将苯并咪唑衍生物，环糊精和水溶性聚合物组合进行包合反应来制备包合络合物 在碱性水溶液中，为了在稳定酸不稳定的苯并咪唑衍生物后配制。