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    Processes for the preparation of cephalosporin derivatives
    1.
    发明申请
    Processes for the preparation of cephalosporin derivatives 有权
    制备头孢菌素衍生物的方法

    公开(公告)号：US20070083042A1

    公开(公告)日：2007-04-12

    申请号：US10577551

    申请日：2004-10-30

    Applicant: Dae Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    Inventor： Dae Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    IPC: C07D501/00

    CPC classification number: C07D501/00 ,  Y02P20/55

    Abstract: Provided is a process for preparing a compound of formula 1 or its salt. The process includes reacting a compound of formula 4 with acetaldehyde in a mixed solvent including water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the presence of a first base to stereospecifically prepare a compound of formula 3 and reacting the compound of the formula 3 with an anhydrous compound of formula 2 in the presence of a second base.

    Abstract translation: 提供制备式1化合物或其盐的方法。 该方法包括在第一碱存在下，使体积比为1:3-6:11〜14的式4化合物与乙醛在包括水，异丙醇和二氯甲烷的混合溶剂中反应，以立体选择性地制备式 3并在第二碱的存在下使式3的化合物与式2的无水化合物反应。

    Processes for the preparation of cephalosporin derivatives
    2.
    发明授权
    Processes for the preparation of cephalosporin derivatives 有权
    制备头孢菌素衍生物的方法

    公开(公告)号：US07622577B2

    公开(公告)日：2009-11-24

    申请号：US10577551

    申请日：2004-10-30

    Applicant: Dae Won Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    Inventor： Dae Won Seo ,  In Hwa Chung ,  Ki Bong Lee ,  In Kyu Lee

    IPC: C07D501/22

    CPC classification number: C07D501/00 ,  Y02P20/55

    Abstract: Provided is a process for preparing a compound of formula 1 or its salt, which comprises reacting a compound represented by the following formula 4 with acetaldehyde in a mixed solvent comprising water, isopropanol, and methylenechloride in a volume ratio of 1:3-6:11-14 in the presence of a first base to stereospecifically prepare a compound represented by the following formula 3′; and reacting the compound of the formula 3′ with an anhydrous compound represented by the following formula 2 in the presence of a second base: wherein R1 is a hydrogen or an amino protecting group, R2 is a hydrogen or a carboxyl protecting group, and R3 is a hydrogen or an amino protecting group consisting of phenylacetyl group, wherein when R3 is a phenylacetyl group, R2 is not a hydrogen in formula 3′; and wherein, when at least one of R2 and R3 is a protecting group, all such protecting groups are removed from formula 3′, thereby producing a compound represented by formula 6 prior to reacting it with the compound of formula 2.

    Abstract translation: 本发明提供制备式1化合物或其盐的方法，该方法包括使下式4表示的化合物与乙醛在含有水，异丙醇和二氯甲烷的混合溶剂中以体积比为1:3-6:3的比例反应， 11-14在第一碱的存在下，立体选择性地制备由下式3'表示的化合物; 并使式3'化合物与下式2表示的无水化合物在第二碱存在下反应：其中R1是氢或氨基保护基，R2是氢或羧基保护基，R3是 是由苯乙酰基组成的氢或氨基保护基，其中当R3是苯乙酰基时，R2不是式3'中的氢; 并且其中当R 2和R 3中的至少一个是保护基时，从式3'中除去所有这些保护基，从而在与式2化合物反应之前制备由式6表示的化合物。

    WAFTER TESTING APPARATUS
    5.
    发明申请
    WAFTER TESTING APPARATUS 审中-公开
    WAFTER测试设备

    公开(公告)号：US20130077651A1

    公开(公告)日：2013-03-28

    申请号：US13535615

    申请日：2012-06-28

    Applicant: Ki-bong LEE

    Inventor： Ki-bong LEE

    IPC: G01N25/66

    CPC classification number: H01L21/67253 ,  G01R31/2874 ,  G05D22/02

    Abstract: A wafer testing apparatus includes a temperature controller for comparing a predetermined first dew point with a second dew point in a prober, and a dry air controller for controlling an amount of dry air supplied into the prober based on a comparison result of the temperature controller.

    Abstract translation: 晶片测试装置包括用于将预定的第一露点与探测器中的第二露点相比较的温度控制器，以及用于根据温度控制器的比较结果来控制供给到探测器中的干燥空气量的干燥空气控制器。

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