公开(公告)号：US20090163461A1

公开(公告)日：2009-06-25

申请号：US11887580

申请日：2006-03-31

申请人： Kazuhiro Shiba ,  Kiichi Ishiwata ,  Hideo Tsukada ,  Shingo Nishiyama

发明人： Kazuhiro Shiba ,  Kiichi Ishiwata ,  Hideo Tsukada ,  Shingo Nishiyama

IPC分类号： A61K31/555 ,  C07D211/22 ,  C07F15/00 ,  A61K31/445

CPC分类号： C07D211/14 ,  A61K51/0457 ,  C07B59/002 ,  C07F7/2208

摘要： The present invention provides a novel compound represented by the formula (I): wherein R1 and R2 are as defined in the specification, or a salt thereof, which is useful as a reagent (radiotracer) for VAChT mapping and the like, and can be used for positron emission tomography (PET), and a production method of the compound. Moreover, the present invention provides a diagnostic reagent for diagnosing cholinergic neurodegenerative disorders (e.g., Alzheimer's disease, memory disorder, learning disorder, schizophrenia, cognitive dysfunction, hyperactivity disorder, anxiety neurosis, depression, analgia, Parkinson's disease and the like) and the like, which contains the aforementioned compound.

摘要翻译： 本发明提供由式（I）表示的新化合物：其中R1和R2如说明书中所定义，或其盐，其用作VAChT作图等的试剂（放射性示踪剂），并且可以是 用于正电子发射断层摄影（PET），以及该化合物的制备方法。 此外，本发明提供了用于诊断胆碱能神经变性疾病（例如阿尔茨海默病，记忆障碍，学习障碍，精神分裂症，认知功能障碍，多动障碍，焦虑性神经症，抑郁，肛门痛，帕金森病等）的诊断试剂， ，其含有上述化合物。