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公开(公告)号:US08052976B2
公开(公告)日:2011-11-08
申请号:US12107571
申请日:2008-04-22
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号: A61K38/18
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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公开(公告)号:US20100167391A1
公开(公告)日:2010-07-01
申请号:US12107571
申请日:2008-04-22
申请人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
发明人: Zeren Gao , Charles E. Hart , Christopher S. Piddington , Paul O. Sheppard , Kimberty E. Shoemaker , Debra G. Gilbertson , James W. West
IPC分类号: C12N5/071
CPC分类号: C07K14/52 , A01K2217/05 , A61K38/1858 , C07K14/475 , C12N2799/022
摘要: Polypeptide growth factors, methods of making them, polynucleotides encoding them, antibodies to them, and methods of using them are disclosed. The polypeptides comprise an amino acid segment that is at least 90% identical to residues 46-163 of SEQ ID NO:2 or residues 235-345 of SEQ ID NO:2. Multimers of the polypeptides are also disclosed. The polypeptides, multimeric proteins, and polynucleotides can be used in the study and regulation of cell and tissue development, as components of cell culture media, and as diagnostic agents.
摘要翻译: 公开了多肽生长因子,其制备方法,编码它们的多核苷酸,针对它们的抗体以及使用它们的方法。 多肽包含与SEQ ID NO:2的残基46-163或SEQ ID NO:2的残基235-345至少90%相同的氨基酸区段。 还公开了多肽的多聚体。 多肽,多聚体蛋白和多核苷酸可用于细胞和组织发育的研究和调节,作为细胞培养基的组分和诊断剂。
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