公开(公告)号：US20140363832A1

公开(公告)日：2014-12-11

申请号：US14344873

申请日：2012-09-14

申请人： Kiyoshi Yanagisawa ,  Takashi Takahashi ,  Kohei Yokoi ,  Yoshinori Hasegawa ,  Ken-ichiro Ono ,  Kasumi Yagi ,  Hitomi Masuda ,  Toshiyuki Takeuchi

发明人： Kiyoshi Yanagisawa ,  Takashi Takahashi ,  Kohei Yokoi ,  Yoshinori Hasegawa ,  Ken-ichiro Ono ,  Kasumi Yagi ,  Hitomi Masuda ,  Toshiyuki Takeuchi

IPC分类号： G01N33/574 ,  C07K16/18

CPC分类号： G01N33/57423 ,  C07K14/47 ,  C07K16/18 ,  G01N33/57407

摘要： The present invention provides a method for testing mesothelioma comprising a step of determining a concentration of a human periostin protein in at least one type of sample of blood or pleural fluid of a subject. In the step of determining the concentration of human periostin protein, an antibody directed against human periostin protein may be used. The present invention further provides a kit for diagnosing mesothelioma, said kit comprising an antibody directed against human periostin protein. In the kit for diagnosing mesothelioma, the antibody directed against a human periostin protein may be an antibody that binds to a polypeptide consisting of an amino acid sequence set out in SE ID NO: 2.

摘要翻译： 本发明提供了一种用于测试间皮瘤的方法，包括测定受试者的至少一种类型的血液或胸膜液样品中人骨膜素蛋白浓度的步骤。 在确定人骨膜素蛋白浓度的步骤中，可以使用针对人骨膜素蛋白的抗体。 本发明还提供了用于诊断间皮瘤的试剂盒，所述试剂盒包含针对人骨膜素蛋白的抗体。 在用于诊断间皮瘤的试剂盒中，针对人骨膜素蛋白的抗体可以是与由SE ID NO：2中列出的氨基酸序列组成的多肽结合的抗体。