公开(公告)号：US20240272085A1

公开(公告)日：2024-08-15

申请号：US18294454

申请日：2022-07-22

Applicant: Kommanditgesellschaft Behnk Elektronik GmbH & Co.

Inventor： Christian Radon

IPC: G01N21/82 ,  G01N21/31 ,  G01N33/86 ,  G16B50/30

CPC classification number: G01N21/82 ,  G01N21/314 ,  G01N33/86 ,  G16B50/30 ,  G01N2021/825

Abstract: What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps:



a. providing platelet-rich plasma “PRP” (17) of a reference blood sample;
b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample;
c. providing platelet-poor plasma “PPP” of the reference blood sample;
d. performing a light transmission measurement on the PPP in order to determine a PPP reference value;
e. assigning the measurement result of step d to the measurement results of step b in a database;
f. repeating steps a to e for a plurality of reference blood samples.




The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value. Once the database has been created, it is possible to determine virtual reference values of blood samples to be examined and perform LTA measurements using the virtual reference values, without the need to obtain PPP from the blood samples to be examined.

公开(公告)号：US12130236B2

公开(公告)日：2024-10-29

申请号：US18294454

申请日：2022-07-22

Applicant: Kommanditgesellschaft Behnk Elektronik GmbH & Co.

Inventor： Christian Radon

IPC: G01N21/82 ,  G01N21/31 ,  G01N33/86 ,  G16B50/30

CPC classification number: G01N21/82 ,  G01N21/314 ,  G01N33/86 ,  G16B50/30 ,  G01N2021/825

Abstract: What is disclosed is a method for creating a database for determining a virtual reference value for a light transmission aggregometry measurement, comprising the following steps:



a. providing platelet-rich plasma “PRP” (17) of a reference blood sample;
b. performing a light transmission measurement with a first light wavelength and a second light wavelength (14), different from the first, on the PRP (17) of the reference blood sample;
c. providing platelet-poor plasma “PPP” of the reference blood sample;
d. performing a light transmission measurement on the PPP in order to determine a PPP reference value;
e. assigning the measurement result of step d to the measurement results of step b in a database;
f. repeating steps a to e for a plurality of reference blood samples.




The database obtained using this method makes it possible to determine a virtual reference value that is an excellent estimate of the PPP reference value. Once the database has been created, it is possible to determine virtual reference values of blood samples to be examined and perform LTA measurements using the virtual reference values, without the need to obtain PPP from the blood samples to be examined.