公开(公告)号：US20100197584A1

公开(公告)日：2010-08-05

申请号：US12670685

申请日：2008-07-25

申请人： Probal Banerjee ,  Krishnaswami Sambasivan Raja

发明人： Probal Banerjee ,  Krishnaswami Sambasivan Raja

IPC分类号： A61K31/12 ,  A61P35/00 ,  A61P35/04 ,  A61K38/22 ,  A61P3/02

CPC分类号： A61K36/9066

摘要： The present invention provides compositions and methods of using curcumin or curcumin derivatives or analogs to activate the pro-apoptotic enzymes caspase-3/7 in cancer cells. The present invention also provides formulations of curcumin or derivatives or analogs with increased solubility or improved bioavailability. The formulations may be administered to a subject such that high concentrations of therapeutically effective curcumin compounds resuit in the subject's bloodstream. The invention thus involves the use of curcumin or curcumin derivatives or analogs to diminish cancer cell growth, decrease tumor size, prevent tumor formation, and Curcumin Carrier to reduce or prevent cancer or tumor cell invasion or metastasis into a tissue, e.g., into the nervous System and especially the brain, of a subject. The instant invention may be used prophylactically to prevent tumor formation or metastasis, as a monotherapy to treat existing tumors, after surgery to prevent recurrence of tumors or in conjunction with conventional cancer therapies to improve patient prognosis and reduce side-effects.

摘要翻译： 本发明提供使用姜黄素或姜黄素衍生物或类似物在癌细胞中活化促凋亡酶半胱天冬酶-3 / 7的组合物和方法。 本发明还提供具有增加的溶解度或改善的生物利用度的姜黄素或衍生物或类似物的制剂。 制剂可以施用于受试者，使得高浓度的治疗有效的姜黄素化合物在受试者的血液中清除。 因此，本发明涉及使用姜黄素或姜黄素衍生物或类似物来减少癌细胞生长，减少肿瘤大小，预防肿瘤形成以及姜黄素载体减少或预防癌症或肿瘤细胞浸入或转移到组织中，例如进入神经元 系统，特别是大脑，一个主题。 本发明可以预防性地用于预防肿瘤形成或转移，作为治疗现有肿瘤的单一疗法，在手术后防止肿瘤复发或与常规癌症疗法结合以改善患者预后并减少副作用。