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12 条记录 (耗时 0.012 秒)

    Novel cell lines, and methods of preparation and use thereof
    3.
    发明申请
    Novel cell lines, and methods of preparation and use thereof 审中-公开
    新型细胞系及其制备方法和用途

    公开(公告)号：US20070190039A1

    公开(公告)日：2007-08-16

    申请号：US10941478

    申请日：2004-09-14

    申请人： Probal Banerjee

    发明人： Probal Banerjee

    IPC分类号： A61K48/00 ,  C12N5/06 ,  C12N5/08 ,  C12N15/09

    CPC分类号： C12N5/0619 ,  C12N2501/01 ,  C12N2510/00

    摘要： The present invention provides, in some embodiments, hippocampal neuron-derived cell lines that display voltage-gated calcium channels of various types, including the N-type channels. Such mixed calcium channel activity is similar to that observed in the hippocampal neurons from which they were originally derived. The cells also can be differentiated into neurons and contain many of the important hippocampal neuron proteins. The invention further provides methods for using the cells.

    摘要翻译： 在一些实施方案中，本发明提供了显示各种类型的电压门控钙通道（包括N型通道）的来自海马神经元的细胞系。 这种混合的钙通道活性与其最初来源于海马神经元的观察相似。 细胞也可以分化为神经元，并含有许多重要的海马神经元蛋白。 本发明还提供了使用这些电池的方法。

    Novel Curcumin-Antibody Conjugates as Anti-Cancer Agents
    4.
    发明申请
    Novel Curcumin-Antibody Conjugates as Anti-Cancer Agents 有权
    新型姜黄素抗体偶联物作为抗癌剂

    公开(公告)号：US20130224229A1

    公开(公告)日：2013-08-29

    申请号：US13513348

    申请日：2010-12-01

    申请人： Probal Banerjee ,  Raja Krishnaswami

    发明人： Probal Banerjee ,  Raja Krishnaswami

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48384 ,  A61K47/50 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865

    摘要： The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents —CH2—CH2— or —CH═CH—; L represents —C(O)—(NH)n1—R—(NH)n2—C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH2—, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.

    摘要翻译： 本发明涉及具有式I的姜黄素衍生物：其中：Z表示：H3COA表示-CH2-CH2-或-CH = CH-; L表示-C（O） - （NH）n1-R-（NH）n2-C（O） - ; R表示链中具有最少3个碳原子的饱和或不饱和的支链或非支链烃基链; 其中链中最大碳原子数为24; 并且其中链的碳原子可以被至少一个杂原子替代，其中杂原子独立地是-O-或-NH2-，条件是每个杂原子彼此分开至少两个碳原子; n1和n2独立地表示0或1; Y表示与肿瘤细胞的靶抗原特异性结合的抗体。 本发明还涉及通过施用有效量的姜黄素衍生物抑制人类肿瘤生长的方法，以及生产姜黄素衍生物的方法。

    USE OF CURCUMIN TO BLOCK BRAIN TUMOR FORMATION IN MICE
    9.
    发明申请
    USE OF CURCUMIN TO BLOCK BRAIN TUMOR FORMATION IN MICE 审中-公开
    使用CURCUMIN阻断大脑中的脑肿瘤形成

    公开(公告)号：US20100197584A1

    公开(公告)日：2010-08-05

    申请号：US12670685

    申请日：2008-07-25

    申请人： Probal Banerjee ,  Krishnaswami Sambasivan Raja

    发明人： Probal Banerjee ,  Krishnaswami Sambasivan Raja

    IPC分类号： A61K31/12 ,  A61P35/00 ,  A61P35/04 ,  A61K38/22 ,  A61P3/02

    CPC分类号： A61K36/9066

    摘要： The present invention provides compositions and methods of using curcumin or curcumin derivatives or analogs to activate the pro-apoptotic enzymes caspase-3/7 in cancer cells. The present invention also provides formulations of curcumin or derivatives or analogs with increased solubility or improved bioavailability. The formulations may be administered to a subject such that high concentrations of therapeutically effective curcumin compounds resuit in the subject's bloodstream. The invention thus involves the use of curcumin or curcumin derivatives or analogs to diminish cancer cell growth, decrease tumor size, prevent tumor formation, and Curcumin Carrier to reduce or prevent cancer or tumor cell invasion or metastasis into a tissue, e.g., into the nervous System and especially the brain, of a subject. The instant invention may be used prophylactically to prevent tumor formation or metastasis, as a monotherapy to treat existing tumors, after surgery to prevent recurrence of tumors or in conjunction with conventional cancer therapies to improve patient prognosis and reduce side-effects.

    摘要翻译： 本发明提供使用姜黄素或姜黄素衍生物或类似物在癌细胞中活化促凋亡酶半胱天冬酶-3 / 7的组合物和方法。 本发明还提供具有增加的溶解度或改善的生物利用度的姜黄素或衍生物或类似物的制剂。 制剂可以施用于受试者，使得高浓度的治疗有效的姜黄素化合物在受试者的血液中清除。 因此，本发明涉及使用姜黄素或姜黄素衍生物或类似物来减少癌细胞生长，减少肿瘤大小，预防肿瘤形成以及姜黄素载体减少或预防癌症或肿瘤细胞浸入或转移到组织中，例如进入神经元 系统，特别是大脑，一个主题。 本发明可以预防性地用于预防肿瘤形成或转移，作为治疗现有肿瘤的单一疗法，在手术后防止肿瘤复发或与常规癌症疗法结合以改善患者预后并减少副作用。

    Curcumin-antibody conjugates as anti-cancer agents
    10.
    发明授权
    Curcumin-antibody conjugates as anti-cancer agents 有权
    姜黄素抗体结合物作为抗癌剂

    公开(公告)号：US09446145B2

    公开(公告)日：2016-09-20

    申请号：US13513348

    申请日：2010-12-01

    申请人： Probal Banerjee ,  Raja Krishnaswami

    发明人： Probal Banerjee ,  Raja Krishnaswami

    IPC分类号： A61K47/48

    CPC分类号： A61K47/48384 ,  A61K47/50 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6865

    摘要： The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H3CO A represents —CH2—CH2— or —CH═CH—; L represents —C(O)—(NH)n1—R—(NH)n2—C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH2—, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative.