公开(公告)号：US20050053988A1

公开(公告)日：2005-03-10

申请号：US10913196

申请日：2004-08-05

申请人： Ira Pastan ,  Kristi Egland ,  Byungkook Lee ,  James Vincent

发明人： Ira Pastan ,  Kristi Egland ,  Byungkook Lee ,  James Vincent

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K14/47 ,  C07K14/705 ,  C12Q1/00 ,  C12Q1/68 ,  G01N33/574

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K39/00 ,  C07K14/705

摘要： A polypeptide is disclosed that is detected in the breast cancer cells termed 68h05. Polynucleotides encoding 68h05 are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind 68h05. Methods are disclosed for using a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05, such as in the treatment of breast cancer or prostate cancer. Assays are disclosed for the detection breast or prostate cancer. Pharmaceutical compositions including a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05 are also disclosed. These pharmaceutical compositions are of use in the treatment of breast or prostate cancer.

摘要翻译： 公开了在称为68h05的乳腺癌细胞中检测到的多肽。 还公开了编码68h05的多核苷酸，以及包括这些多核苷酸的载体也是公开的。 还公开了用这些多核苷酸转化的宿主细胞。 公开了特异性结合68h05的抗体和免疫偶联物。 公开了使用68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的方法，例如用于治疗乳腺癌或前列腺癌。 公开了检测乳腺癌或前列腺癌的检测。 还公开了包含68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的药物组合物。 这些药物组合物可用于治疗乳腺癌或前列腺癌。