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公开(公告)号:US20140170148A1
公开(公告)日:2014-06-19
申请号:US14112848
申请日:2012-04-20
Applicant: Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
Inventor: Bart De Goeij , Patrick Van Berkel , Kristin Strumane , Aran Frank Labrijn , Joost J. Neijssen , Joyce I. Meesters , Paul Parren , Janine Schuurman
IPC: C07K16/32 , A61K45/06 , A61K39/395 , A61K51/10 , A61K47/48
CPC classification number: C07K16/32 , A61K45/06 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6813 , A61K47/6825 , A61K47/6827 , A61K47/6829 , A61K47/6855 , A61K47/6879 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/31 , C07K2317/33 , C07K2317/526 , C07K2317/55 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , A61K39/395 , A61K2300/00
Abstract: Bispecific antibodies which comprise antigen-binding regions binding to two different epitopes of human epidermal growth factor receptor 2 (HER2), and related antibody-based compositions and molecules, are disclosed. Pharmaceutical compositions comprising the antibodies and methods of preparing and using the antibodies are also disclosed.
Abstract translation: 公开了包含与人表皮生长因子受体2(HER2)的两个不同表位结合的抗原结合区的双特异性抗体以及相关的基于抗体的组合物和分子。 还公开了包含抗体的药物组合物和制备和使用抗体的方法。
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公开(公告)号:US20070066803A1
公开(公告)日:2007-03-22
申请号:US11454605
申请日:2006-06-16
Applicant: Frans Roy , Geert Berx , Kristin Strumane
Inventor: Frans Roy , Geert Berx , Kristin Strumane
IPC: C07K14/82 , C07K16/30 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395
CPC classification number: C07K16/2896 , A61K38/1709 , A61K48/00 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2333/705
Abstract: Described is a method of modulating E-cadherin mediated cell adhesion. More specifically, described is the use of hECRep1a and homologues thereof to modulate and/or control tumor cell invasiveness.
Abstract translation: 描述了调节E-钙粘蛋白介导的细胞粘附的方法。 更具体地,描述了hECRep1a及其同源物用于调节和/或控制肿瘤细胞侵袭性的用途。
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公开(公告)号:US20050089896A1
公开(公告)日:2005-04-28
申请号:US10923543
申请日:2004-08-20
Applicant: Frans Roy , Geert Berx , Kristin Strumane
Inventor: Frans Roy , Geert Berx , Kristin Strumane
IPC: A61K38/17 , A61K48/00 , C12Q1/68 , G01N33/50 , G01N33/574
CPC classification number: C07K16/2896 , A61K38/1709 , A61K48/00 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2333/705
Abstract: Described is a method of modulating E-cadherin mediated cell adhesion. More specifically, described is the use of hECRep1a and homologues thereof to modulate and/or control tumor cell invasiveness.
Abstract translation: 描述了调节E-钙粘蛋白介导的细胞粘附的方法。 更具体地,描述了hECRep1a及其同源物用于调节和/或控制肿瘤细胞侵袭性的用途。
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公开(公告)号:US07569668B2
公开(公告)日:2009-08-04
申请号:US11454605
申请日:2006-06-16
Applicant: Frans Van Roy , Geert Berx , Kristin Strumane
Inventor: Frans Van Roy , Geert Berx , Kristin Strumane
IPC: C07K14/00
CPC classification number: C07K16/2896 , A61K38/1709 , A61K48/00 , C07K2317/76 , C12Q1/6886 , C12Q2600/112 , C12Q2600/136 , G01N33/5011 , G01N33/57484 , G01N2333/705
Abstract: Described is a method of modulating E-cadherin mediated cell adhesion. More specifically, described is the use of hECRep1a and homologues thereof to modulate and/or control tumor cell invasiveness.
Abstract translation: 描述了调节E-钙粘蛋白介导的细胞粘附的方法。 更具体地,描述了hECRep1a及其同源物用于调节和/或控制肿瘤细胞侵袭性的用途。
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