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1.发明授权Methods for identifying agents that interact with MAP kinase activated protein kinase 2 失效识别与MAP激酶活化蛋白激酶2相互作用的试剂的方法公开(公告)号：US07167802B2
公开(公告)日：2007-01-23
申请号：US10294027
申请日：2002-11-13
申请人： Kevin D. Parris , Kathryn W. Underwood , Mark L. Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin L. Taylor
发明人： Kevin D. Parris , Kathryn W. Underwood , Mark L. Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin L. Taylor
IPC分类号： G06F19/00
CPC分类号： C12N9/1205 , C07H21/04 , C07K2299/00 , Y02A90/26
摘要： This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.
摘要翻译： 本发明涉及MK2的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定可能与MK2蛋白的活性位点相互作用的试剂。 这样的试剂可用作治疗剂。
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2.发明授权Method for identifying agents that interact with beta-site APP cleaving enzyme (BACE) 失效用于鉴定与β位点APP切割酶（BACE）相互作用的试剂的方法公开(公告)号：US07630838B2
公开(公告)日：2009-12-08
申请号：US09955737
申请日：2001-09-19
申请人： Rajiv Chopra , Kristine Svenson , Bethany Annis Freeman , Tatos N. Akopian , Jonathan Bard , Mark Lloyd Stahl , William S. Somers
发明人： Rajiv Chopra , Kristine Svenson , Bethany Annis Freeman , Tatos N. Akopian , Jonathan Bard , Mark Lloyd Stahl , William S. Somers
CPC分类号： C12N9/6421 , C07K14/4711 , C07K2299/00 , C07K2319/02
摘要： This invention is directed to the three dimensional crystal structure of Beta-site APP Cleaving Enzyme (BACE), and to the use of this structure in rational drug design methods to identify agents that may interact with active sites of BACE. Such agents may represent new therapeutics in the treatment and/or prevention of Alzheimer's Disease.
摘要翻译： 本发明涉及β位点APP裂解酶（BACE）的三维晶体结构，以及在合理药物设计方法中使用该结构来鉴定可能与BACE的活性位点相互作用的试剂。 这样的药剂可代表治疗和/或预防阿尔茨海默病的新疗法。
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公开(公告)号：US20070100560A1
公开(公告)日：2007-05-03
申请号：US11635186
申请日：2006-12-06
申请人： Kevin Parris , Kathryn Underwood , Mark Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin Taylor
发明人： Kevin Parris , Kathryn Underwood , Mark Stahl , Lidia Mosyak , Kristine Svenson , Tania Shane , Meggin Taylor
CPC分类号： C12N9/1205 , C07H21/04 , C07K2299/00 , Y02A90/26
摘要： This invention is directed to the crystal structures of MK2, and to the use of these structures in rational drug design methods to identify agents that may interact with active sites of MK2 proteins. Such agents may be useful as therapeutic agents.
摘要翻译： 本发明涉及MK2的晶体结构，以及在合理的药物设计方法中使用这些结构来鉴定可能与MK2蛋白的活性位点相互作用的试剂。 这样的试剂可用作治疗剂。
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