公开(公告)号：US20240361319A1

公开(公告)日：2024-10-31

申请号：US18687763

申请日：2022-09-09

申请人： TAKEDA VACCINES, INC.

发明人： Betty Elena LUY ,  Shi Hsia HWA ,  Steven Michael ERB ,  Jill A. LIVENGOOD ,  Andrew Montgomery THOMSON

IPC分类号： G01N33/569

CPC分类号： G01N33/56983 ,  G01N2333/185 ,  G01N2469/10

摘要： The present invention provides improved immunofocus assays for determining the virus titer of dengue viruses and the use thereof in the quality control of vaccines based on live attenuated dengue viruses or in the diagnosis of a blood sample from a dengue infected individual.

公开(公告)号：US20240345087A1

公开(公告)日：2024-10-17

申请号：US18633527

申请日：2024-04-12

申请人： Juye Xinhao Agriculture and Animal Husbandry Co. LTD ,  New Hope Liuhe Co., Ltd ,  Xiajin New hope Liuhe agriculture and animal husbandry Co., LTD ,  Shandong new hope Liuhe Group Co., Ltd ,  Shandong New hope Liuhe Agriculture and Animal Husbandry Technology Co. LTD ,  New Hope Group Limited

发明人： Xiaowen Li ,  Jiapei Huang ,  Yang Li ,  Mengli QIAO ,  Jie Qing ,  Zewei WANG ,  Qiannan YU

IPC分类号： G01N33/569 ,  G01N33/543

CPC分类号： G01N33/56983 ,  G01N33/54386 ,  G01N2333/14 ,  G01N2469/20

摘要： This invention provides an ELISA detection kit and method for IgA antibody against Porcine rotavirus group A, belonging to the field of animal husbandry detection technology. The ELISA detection method of this invention utilizes popular PoRV variant strains as parental strains to successfully express recombinant VP6 fusion protein in vitro. Subsequently, the VP6 fusion protein was used as an antigen to be coated onto enzyme-labeled plate to establish a novel ELISA detection method. The method provided by this invention possesses strong sensitivity, high specificity, robust stability, good reproducibility, and ease of preparation, and holds important clinical practical significance for the diagnosis, prevention and control of PoRV.

公开(公告)号：US20240345078A1

公开(公告)日：2024-10-17

申请号：US18633513

申请日：2024-04-12

申请人： The University of Hong Kong ,  Advanced Biomedical Instrumentation Centre Limited

发明人： Yang CAO ,  Ho Cheung SHUM ,  Haisong LIN

IPC分类号： G01N33/543 ,  G01N33/569

CPC分类号： G01N33/54388 ,  G01N33/56983 ,  G01N2333/11 ,  G01N2333/135 ,  G01N2333/165

摘要： The present invention relates to an ultrasensitive rapid antigen detection kit for detecting N protein from SARS-CoV-2 virus in a sample, and methods for detecting N protein. The kit includes a sample collector, a collection and enrichment tube and a rapid antigen detection component with a test strip. The collection and enrichment tube contains a first part containing lyophilized ATPS reagents and a second part containing a lysis buffer. The sample is mixed with the lyophilized ATPS reagents and the lysis buffer to form a mixture. The enrichment is realized by concentrating the target analyte into one of the two phases formed by ATPS.

公开(公告)号：US20240327503A1

公开(公告)日：2024-10-03

申请号：US18550194

申请日：2022-03-11

申请人： Jimmy Dale GOLLIHAR ,  BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

发明人： Jimmy Dale GOLLIHAR ,  Jule GOIKE ,  Ching-Lin HSIEH ,  Andrew P. HORTON ,  Elizabeth GARDNER ,  Daniel BOUTZ ,  Andrew ELLINGTON ,  Edward MARCOTTE ,  Jason S. MCLELLAN ,  George GEORGIOU ,  Gregory C. IPPOLITO

IPC分类号： C07K16/10 ,  A61P31/14 ,  G01N33/569

CPC分类号： C07K16/1003 ,  A61P31/14 ,  G01N33/56983 ,  C07K2317/24 ,  C07K2317/31 ,  G01N2333/165 ,  G01N2469/10

摘要： Provided herein are antibodies and antibody fragments that bind to SARS-COV-2 spike protein. Methods of using these antibodies in in vitro methods are provided. Methods of using these antibodies in vivo to treat or prevent SARS-COV-2 infections are also provided.

公开(公告)号：US12098166B2

公开(公告)日：2024-09-24

申请号：US17291924

申请日：2019-11-05

申请人： BOEHRINGER INGELHEIM VETMEDICA GMBH

发明人： Egbert Siegfried Mundt ,  Xiaoping Cui ,  Zenglei Hu

IPC分类号： C07K14/005 ,  A61K9/00 ,  A61K39/00 ,  A61K39/145 ,  A61K39/39 ,  A61P31/16 ,  C12N7/00 ,  C12N15/86 ,  G01N33/569

CPC分类号： C07K14/005 ,  A61K9/0019 ,  A61K39/145 ,  A61K39/39 ,  A61P31/16 ,  C12N7/00 ,  C12N15/86 ,  G01N33/56983 ,  A61K2039/5252 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/55566 ,  C12N2710/14043 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/16152 ,  C12N2760/16163 ,  C12N2760/16171 ,  G01N2333/11 ,  G01N2469/10

摘要： The invention relates to the field of veterinary medicine. The invention provides an immunogenic composition, comprising a hemagglutinin protein of avian influenza virus H5 subtype. Also provided is a method of differentiating animals naturally infected with AIV from animals vaccinated with the immunogenic composition of the invention. The immunogenic composition of the invention can provide a broader, more effective, long-lasting and early onset protection on poultry.

公开(公告)号：US20240301038A1

公开(公告)日：2024-09-12

申请号：US18552107

申请日：2022-03-24

申请人： Atreca, Inc. ,  University of Vermont and State Agricultural College

发明人： Katherine L. Williams ,  Daniel Eric Emerling ,  Shaun M. Lippow ,  Ngan Nguyen Atkins ,  Jason Botten ,  Annalis Whitaker

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61P31/14 ,  G01N33/569 ,  G01N33/68

CPC分类号： C07K16/1003 ,  A61P31/14 ,  G01N33/56983 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  G01N2333/165

摘要： Described herein are antibodies or variants thereof that specifically bind to coronavirus antigens, such as SARS-CoV-2 antigens. The antibodies can be neutralizing antibodies. Also provided are methods of using the antibodies, including methods of treating a subject infected with SARS-CoV-2, and methods of diagnosing a subject infected with SARS-CoV-2.

公开(公告)号：US20240294965A1

公开(公告)日：2024-09-05

申请号：US18658862

申请日：2024-05-08

申请人： Encodia, Inc.

发明人： Eric OKERBERG ,  Kevin L. Gunderson ,  Norihito Muranaka ,  Jongbum Kim ,  Byung Joon Lim ,  Lei Shi ,  Soumya Ganguly ,  Devin Sullivan

IPC分类号： C12Q1/6804 ,  G01N33/569

CPC分类号： C12Q1/6804 ,  G01N33/56983 ,  G01N2333/165 ,  G01N2458/10 ,  G01N2469/20

摘要： Provided herein are high-throughput, population-wide serotyping and antibody profiling assays. Disclosed variants of a Digital Serotyping assay employ next generation sequencing to measure the “serotyping profile” of barcoded subject serum antibodies tested against a range of DNA-tagged pathogen-derived antigens. The disclosed assay setup enables multiplexing in both the sample and antigen dimensions, generating a large multi-dimensional serotyping data set for more comprehensive serotyping profiling of large populations across a large number of antigens and possible pathogens. Moreover, the ability to easily scale and multiplex the number of peptide epitopes allows rapid updating of the assay content to monitor the ever-changing spectrum of pathogens. Additional applications of this technology include cancer immunology and autoimmune conditions (e.g., neoantigen or autoimmune profiling), screening for toxins, antibody therapeutics development, biosecurity, and veterinary medicine.

公开(公告)号：US20240288429A1

公开(公告)日：2024-08-29

申请号：US18572224

申请日：2022-06-30

申请人： TAUNS Laboratories, Inc.

发明人： Kenji SAITO ,  Sachiko SUZUKI ,  Kazusa MIYATANI

IPC分类号： G01N33/569 ,  C07K16/10 ,  G01N33/543

CPC分类号： G01N33/56983 ,  C07K16/1003 ,  G01N33/54388 ,  G01N2333/165

摘要： The purpose of the present invention is to provide an antibody that enables simple, rapid and sensitive detection of SARS-COV-2, i.e., the causative virus of COVID-19 while suppressing nonspecific reactions, and an immunological detection method and a kit comprising the antibody. By using an antibody that binds to the nucleocapsid protein of SARS-COV-2 or an antibody fragment thereof, in particular, an antibody that recognizes a specific region of the protein or an antibody fragment thereof, provided are a specific and sensitive immunological detection method and kit, in particular, a detection method using a sandwich method such as an immunochromatography method or ELISA method, as well as immunochromatographic test strip containing the antibody and a kit containing the test strip.

公开(公告)号：US20240287527A1

公开(公告)日：2024-08-29

申请号：US18572430

申请日：2022-06-30

申请人： AYASS BIOSCIENCE LLC

发明人： Mohammad Ammar AYASS ,  Lina ABI MOSLEH

IPC分类号： C12N15/115 ,  G01N33/53 ,  G01N33/569

CPC分类号： C12N15/115 ,  G01N33/5308 ,  G01N33/56983 ,  C12N2310/16 ,  C12N2310/3517 ,  G01N2333/165

摘要： Disclosed are novel aptamers that inhibit the binding of a coronaviral S protein to ACE-2 Receptor and methods of their use.

公开(公告)号：US20240287161A1

公开(公告)日：2024-08-29

申请号：US18023957

申请日：2021-09-16

申请人： NATIONAL UNIVERSITY CORPORATION TOTTORI UNIVERSITY

发明人： Yoshimasa TAKAHASHI ,  Taishi ONODERA ,  Yu ADACHI ,  Mitsuo OSHIMURA ,  Yasuhiro KAZUKI ,  Hiroyuki SATOFUKA ,  Takao HASHIGUCHI ,  Katsumi MAENAKA

IPC分类号： C07K16/10 ,  A61K39/00 ,  A61P31/14 ,  G01N33/569

CPC分类号： C07K16/1003 ,  A61P31/14 ,  G01N33/56983 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/76 ,  C07K2317/92 ,  G01N2333/165 ,  G01N2469/10

摘要： Provided is a human antibody against a spike protein of coronavirus, in particular, against a protein in an extracellular region or a receptor-binding domain.