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公开(公告)号：US20100105041A1
公开(公告)日：2010-04-29
申请号：US12518697
申请日：2007-12-14
申请人： Lailing Ku , Charlene Bush-Donovan , Lu-ping Shen
发明人： Lailing Ku , Charlene Bush-Donovan , Lu-ping Shen
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2D6 polymorphisms, in particular CYP2D6 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can be used to predict how an individual will respond to drugs or other xenobiotic compounds that are metabolized, at least in part, by CYP2D6.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于特异性检测临床相关CYP2D6多态性的用途，特别是与不良药物反应相关的CYP2D6多态性。 还提供寡核苷酸序列作为试剂盒组装，其可用于预测个体如何对至少部分由CYP2D6代谢的药物或其他异生物化合物作出反应。
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公开(公告)号：US20100255482A1
公开(公告)日：2010-10-07
申请号：US12741062
申请日：2008-10-29
申请人： Lu-ping Shen , Carrie Li Wong , Lailing Ku , Andy Ying , Charlene Bush-Donovan
发明人： Lu-ping Shen , Carrie Li Wong , Lailing Ku , Andy Ying , Charlene Bush-Donovan
CPC分类号： C12Q1/6883
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and to their use in nucleic acid amplification methods for the detection of HBV in biological samples. In particular, oligonucleotide sequences are provided for the sensitive qualitative or quantitative detection of all eight HBV genotypes. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the diagnosis of HBV infection.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于检测生物样品中HBV的用途。 特别地，提供寡核苷酸序列用于敏感的定性或定量检测所有8种HBV基因型。 本发明还提供用于诊断HBV感染的试剂盒形式的寡核苷酸引物组和引物/探针组。
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公开(公告)号：US20100248220A1
公开(公告)日：2010-09-30
申请号：US12090269
申请日：2006-11-07
申请人： Lailing Ku , Charlene Bush-Donovan , David Sheman , Qi Meng
发明人： Lailing Ku , Charlene Bush-Donovan , David Sheman , Qi Meng
CPC分类号： C12Q1/689 , C12Q1/6818 , C12Q2600/16
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and to their use in nucleic acid amplification methods for the selective and specific detection of Chlamydia trachomatis in biological samples. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the detection and diagnosis of chlamydial infection. The inventive oligonucleotide primers and probes can also be used in combination with other specific oligonucleotide primers and probes for the simultaneous detection of Chlamydia trachomatis and other target organisms, such as Neisseria gonorrhea.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于选择性和特异性检测生物样品中沙眼衣原体的用途。 本发明还提供了用于检测和诊断衣原体感染的试剂盒形式的寡核苷酸引物组和引物/探针组。 本发明的寡核苷酸引物和探针也可以与其它特异性寡核苷酸引物和探针组合使用，用于同时检测沙眼衣原体和其他靶生物，如淋病奈瑟氏球菌。
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公开(公告)号：US07790386B2
公开(公告)日：2010-09-07
申请号：US11784502
申请日：2007-04-06
申请人： Lailing Ku , Charlene Bush-Donovan , David Sherman , Qi Meng
发明人： Lailing Ku , Charlene Bush-Donovan , David Sherman , Qi Meng
CPC分类号： C12Q1/689
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the selective and specific detection of Neisseria gonorrhoeae in biological samples. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the detection and diagnosis of gonococcal infection. The inventive oligonucleotide primers and probes can also be used in combination with other specific oligonucleotide primers and probe for the simultaneous detection of Neisseria gonorrhoeae and other target organisms, such as Chlamydia trachomatis.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于选择性和特异性检测生物样品中淋病奈瑟氏球菌的用途。 本发明还提供了用于检测和诊断淋球菌感染的试剂盒的寡核苷酸引物组和引物/探针组。 本发明的寡核苷酸引物和探针也可以与其它特异性寡核苷酸引物和探针组合使用，用于同时检测淋病奈瑟氏球菌和其它靶生物，如沙眼衣原体。
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公开(公告)号：US20100047800A1
公开(公告)日：2010-02-25
申请号：US12523000
申请日：2008-01-22
申请人： Minxue Zheng , Lailing Ku , Lu-ping Shen , Carrie Wong , Charlene Bush-Donovan
发明人： Minxue Zheng , Lailing Ku , Lu-ping Shen , Carrie Wong , Charlene Bush-Donovan
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/16
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the specific detection of clinically relevant CYP2C9 polymorphisms, in particular CYP2C9 polymorphisms associated with adverse drug response. The oligonucleotide sequences are also provided assembled as kits that can be used to predict how an individual will respond to drugs or other xenobiotic compounds that are metabolized, at least in part, by CYP2C9.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于特异性检测临床相关CYP2C9多态性的用途，特别是与不良药物反应相关的CYP2C9多态性。 还提供寡核苷酸序列组装成试剂盒，其可用于预测个体如何对至少部分由CYP2C9代谢的药物或其它异生素化合物作出反应。
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公开(公告)号：US20080090240A1
公开(公告)日：2008-04-17
申请号：US11784502
申请日：2007-04-06
申请人： Lailing Ku , Charlene Bush-Donovan , David Sherman , Qi Meng
发明人： Lailing Ku , Charlene Bush-Donovan , David Sherman , Qi Meng
CPC分类号： C12Q1/689
摘要： The present invention relates to oligonucleotide sequences for amplification primers and detection probes and their use in nucleic acid amplification methods for the selective and specific detection of Neisseria gonorrhoeae in biological samples. The invention also provides oligonucleotide primer sets and primer/probe sets in the form of kits for the detection and diagnosis of gonococcal infection. The inventive oligonucleotide primers and probes can also be used in combination with other specific oligonucleotide primers and probe for the simultaneous detection of Neisseria gonorrhoeae and other target organisms, such as Chlamydia trachomatis.
摘要翻译： 本发明涉及用于扩增引物和检测探针的寡核苷酸序列及其在核酸扩增方法中用于选择性和特异性检测生物样品中淋病奈瑟氏球菌的用途。 本发明还提供了用于检测和诊断淋球菌感染的试剂盒的寡核苷酸引物组和引物/探针组。 本发明的寡核苷酸引物和探针也可以与其他特异性寡核苷酸引物和探针组合使用，用于同时检测淋病奈瑟氏球菌和其它靶生物，如沙眼衣原体。
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