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1.发明申请INHIBITION OF PRION PROTEIN PROPAGATION BY RECEPTOR ASSOCIATED PROTEIN (RAP), ITS DERIVATIVES, MIMETICS AND SYNTHETIC PEPTIDES 有权受体相关蛋白（RAP）及其衍生物，胶体细胞和合成胶原蛋白的蛋白质扩增抑制作用公开(公告)号：US20120135936A1
公开(公告)日：2012-05-31
申请号：US13265242
申请日：2010-05-17
CPC分类号： C07K14/705 , A61K38/1709
摘要： A pharmaceutical formulation and method of treatment of prion disease include a RAP agent with a pharmaceutically acceptable carrier and/or excipient, and the administration of same to a subject suffering from or at risk of a prion disease. The RAP agent is an effective means for the prevention and/or treatment of various prion diseases regardless whether the disease is acquired by infection or by genetic mutation.
摘要翻译： 药物制剂和治疗朊病毒疾病的方法包括具有药学上可接受的载体和/或赋形剂的RAP试剂，以及将其施用于患有或有朊病毒病风险的受试者。 RAP药剂是预防和/或治疗各种朊病毒疾病的有效手段，无论疾病是通过感染或遗传突变获得的。
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公开(公告)号：US07863411B2
公开(公告)日：2011-01-04
申请号：US10727335
申请日：2003-12-03
IPC分类号： C07K5/00
CPC分类号： G01N33/6896 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K14/47 , G01N2800/2828
摘要： Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.
摘要翻译： 与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。 配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。 来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。 还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法。
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公开(公告)号：US08604161B2
公开(公告)日：2013-12-10
申请号：US12035917
申请日：2008-02-22
IPC分类号： C07K5/00
CPC分类号： G01N33/6896 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K14/47 , G01N2800/2828
摘要： Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject.
摘要翻译： 与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。 配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。 来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。 还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法。
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4.发明申请公开(公告)号：US20050032138A1
公开(公告)日：2005-02-10
申请号：US10823888
申请日：2004-04-14
IPC分类号： A61K20060101 , C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/551 , G01N33/566 , G01N33/68
CPC分类号： G01N33/54306 , G01N33/6896 , G01N2800/2828
摘要： A method of identifying a ligand specific for a structural isoform of a protein by the binding of the structural isoform to a ligand on a support, a direct positional transfer of the structural isoform and a control isoform between two or more different solid or semi-solid supports and detection of at least one of the isoforms on each support, thus allowing for subtractive identification techniques to be used to identify the subset of ligands, or a ligand, specific for the structural isoform.
摘要翻译： 通过结构同种型与支持体上的配体的结合，结构同种型的直接位置转移和两种或多种不同固体或半固体之间的对照同种型来鉴定对蛋白质的结构同种型特异性的配体的方法 支持和检测每个支持物上的至少一种同种型，从而允许消减识别技术用于鉴定对结构亚型特异的配体子集或配体。
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5.发明授权Inhibition of prion propagation by receptor associated protein (RAP), its derivatives, mimetics and synthetic peptides 有权受体相关蛋白（RAP），其衍生物，模拟物和合成肽抑制朊病毒繁殖公开(公告)号：US09051390B2
公开(公告)日：2015-06-09
申请号：US13265242
申请日：2010-05-17
IPC分类号： C07K14/705 , A61K38/17
CPC分类号： C07K14/705 , A61K38/1709
摘要： A pharmaceutical formulation and method of treatment of prion disease include a RAP agent with a pharmaceutically acceptable carrier and/or excipient, and the administration of same to a subject suffering from or at risk of a prion disease. The RAP agent is an effective means for the prevention and/or treatment of various prion diseases regardless whether the disease is acquired by infection or by genetic mutation.
摘要翻译： 药物制剂和治疗朊病毒疾病的方法包括具有药学上可接受的载体和/或赋形剂的RAP试剂，以及将其施用于患有或有朊病毒病风险的受试者。 RAP药剂是预防和/或治疗各种朊病毒疾病的有效手段，无论疾病是通过感染或遗传突变获得的。
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公开(公告)号：US20080268474A1
公开(公告)日：2008-10-30
申请号：US12035917
申请日：2008-02-22
CPC分类号： G01N33/6896 , C07K5/0808 , C07K5/081 , C07K5/0812 , C07K5/0819 , C07K5/0821 , C07K14/47 , G01N2800/2828
摘要： Ligands that bind to prion proteins and methods for using the ligands for detecting or removing a prion protein from a sample, such as a biological fluid or an environmental sample. The ligands are capable of binding to one or more forms of prion protein including cellular prion protein (PrPc), infectious prion protein (PrPsc), and recombinant prion protein (PrPr). Prions from various species, including humans and hamsters, are bound by the ligands. Also provided is a method of treating or retarding the development of a prion-associated pathology in a subject
摘要翻译： 与朊病毒蛋白结合的配体和使用配体检测或从样品例如生物液体或环境样品中除去朊病毒蛋白的方法。 配体能够结合一种或多种形式的朊病毒蛋白，包括细胞朊蛋白（PrPc），感染性朊病毒蛋白（PrPsc）和重组朊蛋白（PrPr）。 来自各种物种的朊病毒，包括人类和仓鼠，都被配体结合。 还提供了治疗或延缓受试者中朊病毒相关病理学发展的方法
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