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1.发明授权Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form 失效创建独特的壳聚糖并采用其与药物形成复合物，在患者体内递送药物和相关剂型的方法
公开(公告)号：US5900408A
公开(公告)日：1999-05-04
申请号：US802311
申请日：1997-02-18
CPC分类号： A61K9/0024 , A61K31/00
摘要： A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3.5 kDa to 250 kDa and preferably about 3.5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization. The layer of the chitosan-drug complex is characterized by a prolonged drug time release property as compared with complexes made from polymerized chitosan. A corresponding method of providing drug delivery to the locale of the implant within a patient is disclosed as is the implant.
摘要翻译： 一种创造独特脱乙酰化的解聚壳聚糖的方法，其可用于提供时间释放壳聚糖 - 药物复合物。 壳聚糖脱乙酰化至少60％，优选至少70％。 优选使用分子量为约3.5kDa至250kDa，优选约3.5kDa至75kDa的壳聚糖。 该复合物可用于各种递送系统，包括片剂，膜，基质支持的药物递送单元或作为植入物上的涂层或膜。 制备药物递送植入物的方法包括提供植入物，产生解聚的壳聚糖和药物的复合物，并在所述植入物的至少一部分上建立壳聚糖药物复合物层。 壳聚糖 - 药物复合物优选通过离子键合产生，并且可以是自身粘附到植入物的外表面的一部分的涂层或膜。 在解聚之前还优选脱乙酰壳聚糖。 与由聚合的壳聚糖制成的复合物相比，壳聚糖 - 药物复合物的层的特征在于延长的药物释放性能。 公开了向植入物内的植入物的位置提供药物递送的相应方法。
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公开(公告)号：US5830883A
公开(公告)日：1998-11-03
申请号：US544428
申请日：1995-11-06
CPC分类号： A61K9/0024 , A61K31/00
摘要： A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3.5 kDa to 250 kDa and preferably about 3.5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization. The layer of the chitosan-drug complex is characterized by a prolonged drug time release property as compared with complexes made from polymerized chitosan. A corresponding method of providing drug delivery to the locale of the implant within a patient is disclosed as is the implant.
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