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135 条记录 (耗时 0.03 秒)

    Biopolymer system for tissue sealing
    1.
    发明授权
    Biopolymer system for tissue sealing 有权
    用于组织密封的生物聚合物体系

    公开(公告)号：US07854923B2

    公开(公告)日：2010-12-21

    申请号：US11530362

    申请日：2006-09-08

    申请人： Weiliam Chen ,  John M. Abrahams

    发明人： Weiliam Chen ,  John M. Abrahams

    IPC分类号： A61K48/00 ,  A61K31/73

    CPC分类号： A61L26/0052 ,  A61K9/0085 ,  A61K9/06 ,  A61K31/721 ,  A61K31/722 ,  A61K38/1875 ,  A61K47/60 ,  A61K47/6903 ,  A61K48/00 ,  A61K49/0002 ,  A61K49/0457 ,  A61K51/1213 ,  A61L24/0031 ,  A61L24/043 ,  A61L24/08 ,  A61L24/104 ,  A61L26/0066 ,  A61L26/008 ,  A61L26/009 ,  A61L2300/232 ,  A61L2300/236 ,  C08L89/00 ,  C08L5/08

    摘要： A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

    摘要翻译： 提供了用于外科和医疗程序中用于密封活体哺乳动物的组织的组织密封剂。 组织密封剂包括水凝胶，其通过凝胶化设置在要密封的组织上的预混物而形成。 该预混合物在水性介质中包含烷基化壳聚糖或明胶，以及多元羧酸或氧化多糖。 预混合物还可以包括脱水剂，羧基活化剂或两者。 组织密封剂的具体用途是在脑外科手术后修复硬膜，以防止脑脊液漏出。 组织密封剂可以包括治疗剂或保护剂，例如抗生素或抗炎药。

    Chondroprotective/restorative compositions and methods of use thereof
    2.
    发明授权
    Chondroprotective/restorative compositions and methods of use thereof 失效
    软骨保护/修复组合物及其使用方法

    公开(公告)号：US06924273B2

    公开(公告)日：2005-08-02

    申请号：US09967977

    申请日：2001-10-02

    申请人： Scott W. Pierce

    发明人： Scott W. Pierce

    IPC分类号： A23K1/18 ,  A61K31/7008 ,  A61K31/728 ,  A01N65/00 ,  A61K38/16 ,  A61K31/73

    CPC分类号： A61K31/728 ,  A23K50/20 ,  A61K31/7008 ,  A61K2300/00

    摘要： The instant invention provides a method of treating or preventing osteoarthritis, joint effusion, joint inflammation and pain, synovitis, lameness, post operative arthroscopic surgery, deterioration of proper joint function including joint mobility, the reduction or inhibition of metabolic activity of chondrocytes, the activity of enzymes that degrade cartilage, the reduction or inhibition of the production of Hyaluronic acid, said method comprising orally administering to a mammalian species a therapeutically effective amount of Hyaluronic Acid or pharmaceutically acceptable salts thereof. Additionally, compositions containing hyaluronic acid; chondroitin sulfate, and glucosamine sulfate in a paste formulation are also disclosed which can be administered on their own or can be used as a feed additive.

    摘要翻译： 本发明提供了治疗或预防骨关节炎，关节积液，关节炎症和疼痛，滑膜炎，跛行，术后关节镜手术，适当关节功能恶化（包括关节活动性），减少或抑制软骨细胞代谢活性的方法 的降解软骨的酶，减少或抑制透明质酸的产生，所述方法包括向哺乳动物物种口服施用治疗有效量的透明质酸或其药学上可接受的盐。 另外，含有透明质酸的组合物; 还公开了一种糊剂制剂中的硫酸软骨素和硫酸葡萄糖胺，其可以单独施用或可以用作饲料添加剂。

    Method of promoting dermal wound healing with chitosan and heparin or heparin sulfate
    3.
    发明授权
    Method of promoting dermal wound healing with chitosan and heparin or heparin sulfate 失效
    用壳聚糖和肝素或硫酸肝素促进皮肤伤口愈合的方法

    公开(公告)号：US5902798A

    公开(公告)日：1999-05-11

    申请号：US765353

    申请日：1996-12-31

    申请人： Ibrahim Gouda ,  Olle Larm

    发明人： Ibrahim Gouda ,  Olle Larm

    IPC分类号： A61K47/38 ,  A61K31/715 ,  A61K31/722 ,  A61K31/727 ,  A61K31/737 ,  A61L15/28 ,  A61L15/44 ,  A61L26/00 ,  A61P17/00 ,  A61P17/02 ,  A61P43/00 ,  A61K31/73 ,  A61K31/725 ,  A61K35/56

    CPC分类号： A61K31/722 ,  A61K31/727 ,  A61L15/28 ,  A61L26/0023

    摘要： The invention relates to a method for promoting the healing of dermal wounds by applying a composition containing chitosan and the polysaccharide, heparin or heparan sulfate. Heparin or heparan sulfate can be immobilized to chitosan by ionic or covalent bonds, and the degree of N-acetylation of chitosan can range from 25% to 90%. The composition can include a cellulose derivative as an additional polysaccharide to increase the viscosity of the composition. The combination of chitosan and polysaccharide, when applied to a wound site, effectively stimulates and accelerates wound healing.

    摘要翻译： PCT No.PCT / SE95 / 00875 Sec。 371日期1996年12月31日第 102（e）1996年12月31日PCT PCT 1995年7月18日PCT公布。 公开号WO96 / 02260 日期1996年2月1日本发明涉及通过应用含有壳聚糖和多糖，肝素或硫酸乙酰肝素的组合物来促进皮肤伤口愈合的方法。 肝素或硫酸乙酰肝素可以通过离子或共价键固定在壳聚糖上，壳聚糖的N-乙酰化程度可以在25％〜90％之间。 组合物可以包括纤维素衍生物作为另外的多糖以增加组合物的粘度。 当应用于伤口部位时，壳聚糖和多糖的组合有效地刺激和加速伤口愈合。

    Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form
    8.
    发明授权
    Methods of creating a unique chitosan and employing the same to form complexes with drugs, delivery of the same within a patient and a related dosage form 失效

    公开(公告)号：US5830883A

    公开(公告)日：1998-11-03

    申请号：US544428

    申请日：1995-11-06

    申请人： Lawrence H. Block ,  Shobhan S. Sabnis

    发明人： Lawrence H. Block ,  Shobhan S. Sabnis

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61K31/00 ,  A61K31/73 ,  A61F13/00

    CPC分类号： A61K9/0024 ,  A61K31/00

    摘要： A method of creating a unique deacetylated, depolymerized chitosan which may be employed to provide a time release chitosan-drug complex. The chitosan is deacetylated at least 60 percent and preferably at least 70 percent. It is preferred to employ a chitosan having a molecular weight of about 3.5 kDa to 250 kDa and preferably about 3.5 kDa to 75 kDa. The complex may be employed in various delivery systems including tablets, films, matrix supported drug delivery units or as coatings or films on implants. A method of making a drug delivering implant includes providing an implant, creating a complex of a depolymerized chitosan and a drug and establishing a layer of a chitosan drug complex on at least a portion of said implant. The chitosan-drug complex is preferably created through ionic bonding and may be a coating or a film self-adhered to a portion of an exterior surface of the implant. It is also preferred to deacetylate the chitosan prior to depolymerization. The layer of the chitosan-drug complex is characterized by a prolonged drug time release property as compared with complexes made from polymerized chitosan. A corresponding method of providing drug delivery to the locale of the implant within a patient is disclosed as is the implant.

    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine biological barriers
    10.
    发明授权
    Methods and compositions for poly-.beta.-1-4-N-acetylglucosamine biological barriers 失效
    聚-β-1-4-N-乙酰葡糖胺生物屏障的方法和组成

    公开(公告)号：US5624679A

    公开(公告)日：1997-04-29

    申请号：US470083

    申请日：1995-06-06

    申请人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    发明人： John N. Vournakis ,  Sergio Finkielsztein ,  Ernest R. Pariser ,  Mike Helton

    IPC分类号： A61K9/20 ,  A61K47/48 ,  A61L15/28 ,  A61L31/04 ,  C08B37/08 ,  C12N5/00 ,  C12P19/26 ,  C08L5/08 ,  A61K31/73

    CPC分类号： A61K9/205 ,  A61K47/4823 ,  A61K47/48769 ,  A61L15/28 ,  A61L31/042 ,  C08B37/003 ,  C12N5/0068 ,  C12P19/26 ,  C12R1/89 ,  C12N2533/70

    摘要： The present invention relates to a purified, easily produced poly-.beta.-1.fwdarw.4-N-acetylglucosamine (p-GlcNAc) polysaccharide species. The p-GlcNAc of the invention is a polymer of high molecular weight whose constituent monosaccharide sugars are attached in a .beta.-1.fwdarw.4 conformation, and which is free of proteins, and substantially free of single amino acids, and other organic and inorganic contaminants. In addition, derivatives and reformulations of p-GlcNAc are described. The present invention further relates to methods for the purification of the p-GlcNAc of the invention from microalgae, preferably diatom, starting sources. Still further, the invention relates to methods for the derivatization and reformulation of the p-GlcNAc. Additionally, the present invention relates to the uses of pure p-GlcNAc, its derivatives, and/or its reformulations.

    摘要翻译： 本发明涉及一种纯化的，容易制备的多聚-β-1-4-N-乙酰氨基葡萄糖（p-GlcNAc）多糖物种。 本发明的p-GlcNAc是一种高分子量的聚合物，其构成单糖以β-1→4构象连接，并且不含蛋白质，基本上不含单一氨基酸和其它有机和无机 污染物 此外，描述了p-GlcNAc的衍生物和重组。 本发明还涉及从微藻，优选硅藻，起始源纯化本发明的p-GlcNAc的方法。 此外，本发明涉及p-GlcNAc的衍生化和重新配制的方法。 另外，本发明涉及纯p-GlcNAc，其衍生物和/或其重新配制体的用途。