公开(公告)号：US20050130241A1

公开(公告)日：2005-06-16

申请号：US10468949

申请日：2002-02-22

申请人： Lena Carlsson ,  Ove Nilsson ,  Gunnar Ronquist ,  Anders Larsson

发明人： Lena Carlsson ,  Ove Nilsson ,  Gunnar Ronquist ,  Anders Larsson

IPC分类号： G01N33/574 ,  G01N33/53 ,  C07K16/42 ,  G01N33/537 ,  G01N33/543

CPC分类号： G01N33/57434

摘要： The present invention relates to a diagnostic and/or prognostic reagent comprising a component which selectively binds to anti-prostasome autoantibodies, as well as an immunoassay using said reagent. Furthermore, the invention relates to an in vitro method for diagnosing and/or prognosticating a condition reflecting the prostasome presence in body fluids, comprising a) binding of anti-prostasome autoantibodies with a component which selectively binds to anti-prostasome autoantibodies; and b) detection of said binding. The conditions may be different forms of prostate cancer or prostasome-related diseases or other conditions where anti-prostasome autoantibodies are present in the body.

摘要翻译： 本发明涉及包含选择性结合抗前列腺自身抗体的组分的诊断和/或预后试剂，以及使用所述试剂的免疫测定。 此外，本发明涉及用于诊断和/或预测反映体液中前列腺体存在的病症的体外方法，其包括：a）抗前列腺素自身抗体与选择性结合抗前列腺自身抗体的成分的结合; 和b）检测所述结合。 这些病症可能是前列腺癌或前列腺体相关疾病或其他抗前列腺炎自身抗体存在于体内的其他病症的不同形式。

公开(公告)号：US20130040849A1

公开(公告)日：2013-02-14

申请号：US13641424

申请日：2011-04-18

申请人： Rune Eliasson ,  Nils Egberg ,  Lena Carlsson ,  Gunnar Ronquist ,  Anders Larsson ,  Goran Ronquist

发明人： Rune Eliasson ,  Nils Egberg ,  Lena Carlsson ,  Gunnar Ronquist ,  Anders Larsson ,  Goran Ronquist

IPC分类号： G01N33/574 ,  G01N21/64 ,  C07K16/28 ,  C40B30/04

CPC分类号： G01N33/57434 ,  G01N2800/52

摘要： A method for diagnosing or providing a prognosis of a subject suspected of suffering from prostate cancer, comprising in vitro detection of prostasomes and quantification of prostasomal expression of at least one antigen chosen from the group consisting of CD13, CD59, CD10, CD26 CD142, CD143 and MHC I, and comparing said quantified expression value with a reference value for the respective antigen derived from healthy subject(s). Quotients between said antigens may moreover be made use of. Detection may be by way of flow cytometry or ELISA. A kit for use in diagnosis or providing a prognosis of a subject suspected of suffering from prostate cancer is furthermore provided.

摘要翻译： 一种用于诊断或提供怀疑患有前列腺癌的受试者的预后的方法，包括体外检测前列腺体并定量选自CD13，CD59，CD10，CD26 CD142，CD143中的至少一种抗原的前列腺表达 和MHC I，并将所述定量表达值与来自健康受试者的各抗原的参考值进行比较。 此外，可以使用所述抗原之间的术语。 检测可能是通过流式细胞术或ELISA。 还提供了用于诊断或提供疑似患有前列腺癌的受试者的预后的试剂盒。