公开(公告)号：US07489965B2

公开(公告)日：2009-02-10

申请号：US10957930

申请日：2004-10-04

申请人： Ying Sun ,  Jiang Wu ,  Leon P. Collis ,  Robert B. Hill

发明人： Ying Sun ,  Jiang Wu ,  Leon P. Collis ,  Robert B. Hill

IPC分类号： A61N1/00

CPC分类号： A61N1/32 ,  A61B5/05 ,  A61B5/4041 ,  A61B5/4047

摘要： A dynamically configurable clamping device for applying a desired electrical current to a tissue membrane includes an input lead electrically connected to the tissue membrane to provide a sensed signal indicative of voltage across the membrane. An input circuit includes an analog-to-digital converter, and is responsive to the sensed signal and provides a digitized signal indicative of the sensed signal. A digital signal processor executes selected program instructions to operate in a selected one of (i) a voltage clamp mode, (ii) a current clamp mode or (iii) a dynamic clamp mode based upon the state of a mode selection signal indicative of the selected operating mode. The digital signal processor provides a digital current command signal indicative of the current to be applied to the tissue membrane. An output circuit receives the digital current command signal, and generates a current signal indicative thereof. An output lead receives and applies the current signal to the tissue membrane. Digital feedback control is advantageous over the traditional systems by providing programmability, capability for dynamic changes of clamping modes, hardware simplification, and integration of multi-channel clamping systems. The digital signal processor in the feedback loop provides programmability in the control algorithm.

摘要翻译： 用于向组织膜施加期望的电流的动态配置的钳位装置包括电连接到组织膜的输入引线，以提供指示穿过膜的电压的感测信号。 输入电路包括模数转换器，并响应于所感测的信号，并提供指示感测信号的数字化信号。 数字信号处理器执行所选择的程序指令以在（i）电压钳位模式，（ii）电流钳位模式或（iii）动态钳位模式中选择的一个中基于表示模式选择信号的状态 选择操作模式。 数字信号处理器提供指示要施加到组织膜的电流的数字电流命令信号。 输出电路接收数字电流指令信号，并产生指示其的电流信号。 输出引线接收并施加电流信号到组织膜。 数字反馈控制通过提供可编程性，对钳位模式的动态变化，硬件简化和多通道钳位系统的集成的能力，对传统系统是有利的。 反馈环路中的数字信号处理器在控制算法中提供可编程性。