-
公开(公告)号：US5013833A
公开(公告)日：1991-05-07
申请号：US258908
申请日：1988-10-18
IPC分类号： C07D501/00 , A61K20060101 , A61K31/19 , A61K31/325 , A61K31/34 , A61K31/54 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D20060101 , C07D501/02 , C07D501/04 , C07D501/12 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/46
CPC分类号： C07D501/34
摘要： There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
-
公开(公告)号：US4453574A
公开(公告)日：1984-06-12
申请号：US256402
申请日：1981-04-22
申请人： Leonard G. Elliott
发明人： Leonard G. Elliott
摘要： Liquid additives can be supplied to a fermenter vessel from a reservoir by a dispensing device which comprises a central discharge chamber connected in series between an upper escape chamber and a lower inlet chamber. These chambers are arranged to provide a smooth passage for liquid and do not have any steps or recesses therein. An escape port leading from the upper end of the escape chamber to the reservoir is controlled by a valve member. An inlet port leads into the lower end of the inlet chamber from the reservoir and is controlled by a valve member. A discharge port leads from the bottom end of the discharge chamber and is controlled by a valve member. A pressure equalizing port leads to the top end of the discharge chamber and is controlled by a valve member. The discharge and pressure equalizing ports are connected to the upper portion of the fermenter vessel. The escape chamber is capable of retaining liquid therein by interfacial tension while liquid is discharged from the discharge chamber. If desired, the discharge chamber may be divided into a plurality of sub-chambers.
摘要翻译： 液体添加剂可以通过分配装置从储存器供应到发酵罐中，分配装置包括串联连接在上部逸出室和下部入口室之间的中心排出室。 这些室被布置成为液体提供平滑通道，并且在其中没有任何台阶或凹陷。 从排气室的上端引导到贮存器的排出口由阀构件控制。 入口端口从储存器引入入口室的下端，并由阀构件控制。 排出口从排出室的底端引出并由阀构件控制。 压力平衡端口通向排出室的顶端并由阀构件控制。 排放和均压口连接到发酵罐的上部。 逃逸室能够通过界面张力保持液体，而液体从排出室排出。 如果需要，排放室可以被分成多个子室。
-
公开(公告)号：US4865851A
公开(公告)日：1989-09-12
申请号：US193784
申请日：1988-05-13
CPC分类号： A61K9/0095 , A61K31/545 , A61K9/1617 , A61K9/1652 , A61K9/5015
摘要： Cefuroxime axetil in particulate form is coated with an integral coating of a lipid or mixture of lipids which serves to mask the bitter taste of cefuroxime axetil but disperses or dissolves on contact with gastrointestinal fluid. The resulting particles may be incorporated into pharmaceutical compositions for oral administration, for instance aqueous suspensions.
摘要翻译： 颗粒形式的头孢呋辛酯包被脂质或脂质混合物的整体涂层，其用于掩蔽头孢呋辛酯的苦味，但在与胃肠液接触时分散或溶解。 所得到的颗粒可以并入用于口服给药的药物组合物中，例如水性悬浮液。
-
4.发明授权Preparation of a highly pure, substantially amorphous form of cefuroxime axetil 失效制备高纯度，基本无定形形式的头孢呋辛酯
公开(公告)号：US4820833A
公开(公告)日：1989-04-11
申请号：US938140
申请日：1986-12-04
IPC分类号： C07D501/00 , A61K20060101 , A61K31/19 , A61K31/325 , A61K31/34 , A61K31/54 , A61K31/545 , A61K31/546 , A61P31/04 , C07C20060101 , C07D20060101 , C07D501/02 , C07D501/04 , C07D501/12 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/46
CPC分类号： C07D501/34
摘要： There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.
-
-
-
搜索结果
4 条记录 (耗时 0.013 秒)
