公开(公告)号：US08372468B2

公开(公告)日：2013-02-12

申请号：US12547839

申请日：2009-08-26

申请人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

发明人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

IPC分类号： B05D5/08 ,  B05D3/00

CPC分类号： B05D5/08 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/18 ,  C08J3/245 ,  C08J7/06 ,  C08L23/0853 ,  C08L83/04 ,  C08L2666/04

摘要： A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

摘要翻译： 一种具有外表面并且包括具有用硅烷表面改性剂处理的内表面的至少一个内腔的医疗电引线体，以在所述内表面的至少一部分上形成三维密集交联的光滑涂层 流明。 引线体的外表面也可以被类似地处理。 与未涂覆的表面相比，润滑硅烷涂层可以将引线体的涂覆表面的摩擦系数降低多达80％。 摩擦系数的降低可以提高导体通过引线体腔的穿线效率并且可以提高其耐磨性。

公开(公告)号：US20130122185A1

公开(公告)日：2013-05-16

申请号：US13735530

申请日：2013-01-07

申请人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

发明人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

IPC分类号： B05D5/08

CPC分类号： B05D5/08 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/18 ,  C08J3/245 ,  C08J7/06 ,  C08L23/0853 ,  C08L83/04 ,  C08L2666/04

摘要： A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

摘要翻译： 一种具有外表面并且包括具有用硅烷表面改性剂处理的内表面的至少一个内腔的医疗电引线体，以在所述内表面的至少一部分上形成三维密集交联的光滑涂层 流明。 引线体的外表面也可以被类似地处理。 与未涂覆的表面相比，润滑硅烷涂层可以将引线体的涂覆表面的摩擦系数降低多达80％。 摩擦系数的降低可以提高导体通过引线体腔的穿线效率并且可以提高其耐磨性。

公开(公告)号：US20100075018A1

公开(公告)日：2010-03-25

申请号：US12547839

申请日：2009-08-26

申请人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

发明人： Shrojalkumar Desai ,  Leslie J. Carion ,  Larry L. Hum

IPC分类号： B05D5/08 ,  B05D3/00

CPC分类号： B05D5/08 ,  A61L31/10 ,  A61L31/14 ,  A61L2400/18 ,  C08J3/245 ,  C08J7/06 ,  C08L23/0853 ,  C08L83/04 ,  C08L2666/04

摘要： A medical electrical lead body having an outer surface and including at least one lumen having an inner surface treated with a silane surface modifying agent to form a three-dimensional, densely cross-linked lubricious coating over at least a portion of the inner surface of the lumen. The outer surface of the lead body also may be similarly treated. The lubricious silane coating may reduce the coefficient of friction of the coated surface of the lead body by as much as 80% when compared to an uncoated surface. A reduction in the coefficient of friction may enhance the stringing efficiency of a conductor through the lead body lumen and may enhance its abrasion resistance.

摘要翻译： 一种具有外表面并且包括具有用硅烷表面改性剂处理的内表面的至少一个内腔的医疗电引线体，以在所述内表面的至少一部分上形成三维密集交联的光滑涂层 流明。 引线体的外表面也可以被类似地处理。 与未涂覆的表面相比，润滑硅烷涂层可以将引线体的涂覆表面的摩擦系数降低多达80％。 摩擦系数的降低可以提高导体通过引线体腔的穿线效率并且可以提高其耐磨性。

公开(公告)号：US08160721B2

公开(公告)日：2012-04-17

申请号：US12508322

申请日：2009-07-23

申请人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

发明人： Daniel J. Cooke ,  Leslie J. Carion ,  Shrojalkumar Desai ,  Brendan E. Koop ,  Ronald W. Heil, Jr. ,  Harshad M. Borgaonkar ,  Matthew S. Finlay

IPC分类号： A61N1/00

CPC分类号： A61N1/057 ,  A61N1/0568

摘要： A medical electrical lead comprises a flexible, elongate lead body extending along a longitudinal axis and having a proximal end and a distal end. A protective distal tip structure is disposed on the distal end of the lead body. The tip structure includes a plurality of compliant projections each extending distally from the distal end of the body in the direction of the longitudinal axis. The projections are configured to contact and bear against cardiac tissue when the lead is implanted, and are deformable under the action of an axially or radially directed force. The projections optionally include a coating over a substrate. The coating can include a hydrogel material and/or a pharmaceutical agent such as a steroid for reducing inflammation at the implantation site.

摘要翻译： 医疗电引线包括沿着纵向轴线延伸并且具有近端和远端的柔性细长引线体。 保护性的顶端结构设置在引线体的远端。 尖端结构包括多个顺从突起，每个突起从纵向轴线的方向远离主体的远端延伸。 突起被配置为当铅被植入时与心脏组织接触并承受，并且在轴向或径向力的作用下可变形。 突起任选地包括在基底上的涂层。 涂层可以包括水凝胶材料和/或药剂，例如类固醇，用于在植入部位减少炎症。