公开(公告)号：US5556777A

公开(公告)日：1996-09-17

申请号：US118989

申请日：1993-09-09

申请人： Glynn T. Faircloth, Jr. ,  Francisco R. Millan ,  Librada M. C. Fernandez ,  Cristina A. Sarabia

发明人： Glynn T. Faircloth, Jr. ,  Francisco R. Millan ,  Librada M. C. Fernandez ,  Cristina A. Sarabia

IPC分类号： C07D405/14 ,  C12P17/16 ,  C12N1/20

CPC分类号： C07D405/14 ,  C12P17/16

摘要： The active component of the pharmaceutical composition of the present invention is a compound which has been isolated from the controlled aerobic fermentation of a marine microorganism, Agrobacterium sp. PH-103. The pharmaceutical compositions of the present invention, useful for post surgical graft tolerance, are thus directed to compositions comprising a pharmaceutically acceptable carrier, diluent or excipient, and an effective amount of the compound having the formula: ##STR1## This compound, known as Sesbanimide, is an alkaloid that has been previously been isolated from seeds and reported to be useful as an antitumor drug. Prior to the present invention however, this compound had not been isolated from any fermentation broth nor had it been determined to have immunomodulatory activity.

摘要翻译： 本发明的药物组合物的活性组分是从海洋微生物农杆菌属的受控好氧发酵中分离的化合物。 PH-103。 因此，可用于手术后移植物耐受性的本发明的药物组合物涉及包含药学上可接受的载体，稀释剂或赋形剂和有效量的具有下式的化合物的组合物：该化合物，称为Sesbanimide 是以前已经从种子中分离并据报道可用作抗肿瘤药物的生物碱。 然而，在本发明之前，该化合物没有从任何发酵液中分离，也没有确定具有免疫调节活性。