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公开(公告)号:US20110091488A1
公开(公告)日:2011-04-21
申请号:US12835436
申请日:2010-07-13
申请人: Janet A. HALLIDAY , Jukka TUOMINEN , Mark LIVINGSTONE , Frank KOPPENHAGEN , Lilias CURRIE , Sarah STEWART
发明人: Janet A. HALLIDAY , Jukka TUOMINEN , Mark LIVINGSTONE , Frank KOPPENHAGEN , Lilias CURRIE , Sarah STEWART
IPC分类号: A61K47/34 , C08G18/00 , A61K31/5575 , A61K31/70 , A61K38/11 , A61K31/56 , A61K38/28 , A61K38/22 , A61K39/00
CPC分类号: A61K47/34 , A61K9/02 , A61K31/215 , C08G18/6674 , C08G18/758 , C08G2210/00
摘要: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swellable linear polymer obtainable by reacting together: (a) a dried polyethylene oxide; (b) a dried C5 to C20 diol; and (c) a Bifunctional diisocyanate; and (II) a releasable pharmaceutically active agent.
摘要翻译: 提供了固体剂型的药物控释组合物,其包含(I)可通过一起反应获得的水溶胀性线性聚合物:(a)干燥的聚环氧乙烷; (b)干燥的C5至C20二醇; 和(c)双官能二异氰酸酯; 和(II)可释放的药物活性剂。
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公开(公告)号:US20060134161A1
公开(公告)日:2006-06-22
申请号:US10528875
申请日:2003-09-26
申请人: Janet Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
发明人: Janet Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
CPC分类号: A61K47/34 , A61K9/02 , A61K31/215 , C08G18/6674 , C08G18/758 , C08G2210/00
摘要: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.
摘要翻译: 通过使聚环氧乙烷(例如PEG 4000〜35,000),双官能化合物(例如二胺或二醇,例如1,10-癸二醇)与二异氰酸酯反应形成水溶胀性线性聚氨酯聚合物。 三种成分的比例通常为0.1〜1.5〜1〜1.1〜2.5。 聚氨酯的水溶胀范围为300〜1700%,可溶于某些有机溶剂如二氯甲烷。 它可以装载特别是高分子量的药物活性剂,以产生控释组合物,例如子宫托等。
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公开(公告)号:US08628798B2
公开(公告)日:2014-01-14
申请号:US13571596
申请日:2012-08-10
申请人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
发明人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
IPC分类号: A61K9/22 , A61K31/215
CPC分类号: A61K47/34 , A61K9/02 , A61K31/215 , C08G18/6674 , C08G18/758 , C08G2210/00
摘要: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.
摘要翻译: 通过使聚环氧乙烷(例如PEG 4000〜35,000),双官能化合物(例如二胺或二醇,例如1,10-癸二醇)与二异氰酸酯反应形成水溶胀性线性聚氨酯聚合物。 三种成分的比例通常为0.1〜1.5〜1〜1.1〜2.5。 聚氨酯的水溶胀范围为300〜1700%,可溶于某些有机溶剂如二氯甲烷。 它可以装载特别是高分子量的药物活性剂,以产生控释组合物,例如子宫托等。
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公开(公告)号:US08557281B2
公开(公告)日:2013-10-15
申请号:US12835436
申请日:2010-07-13
申请人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
发明人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
IPC分类号: A61K38/11
CPC分类号: A61K47/34 , A61K9/02 , A61K31/215 , C08G18/6674 , C08G18/758 , C08G2210/00
摘要: A pharmaceutical controlled release composition in solid dosage form is provided which comprises (I) a water-swell able linear polymer obtainable by reacting together: (a) a polyethylene oxide; (b) a C5 to C20 diol; and (c) a diisocyanate; and (II) a releasable pharmaceutically active agent.
摘要翻译: 提供了一种固体剂型的药物控释组合物,其包括(I)可通过一起反应获得的水溶胀性线性聚合物:(a)聚环氧乙烷; (b)C5〜C20二醇; 和(c)二异氰酸酯; 和(II)可释放的药物活性剂。
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公开(公告)号:US20120302635A1
公开(公告)日:2012-11-29
申请号:US13571596
申请日:2012-08-10
申请人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
发明人: Janet A. Halliday , Jukka Tuominen , Mark Livingstone , Frank Koppenhagen , Lilias Currie , Sarah Stewart
IPC分类号: A61K47/34
CPC分类号: A61K47/34 , A61K9/02 , A61K31/215 , C08G18/6674 , C08G18/758 , C08G2210/00
摘要: A water-swellable linear polyurethane polymer is formed by reacting a polyethylene oxide (e.g. PEG 4000 to 35,000), a difunctional compound (e.g. a diamine or diol such as 1,10-decanediol) with a diisocyanate. The ratio of the three components is generally in the range 0.1-1.5 to 1 to 1.1-2.5. The polyurethane is water-swellable in the range 300 to 1700% and soluble in certain organic solvents such as dichloromethane. It can be loaded with pharmaceutically active agents, particularly of high molecular weight, to produce controlled release compositions, such as pessaries etc.
摘要翻译: 通过使聚环氧乙烷(例如PEG 4000〜35,000),双官能化合物(例如二胺或二醇,例如1,10-癸二醇)与二异氰酸酯反应形成水溶胀性线性聚氨酯聚合物。 三种成分的比例通常为0.1〜1.5〜1〜1.1〜2.5。 聚氨酯的水溶胀范围为300〜1700%,可溶于某些有机溶剂如二氯甲烷。 它可以装载特别是高分子量的药物活性剂,以产生控释组合物,例如子宫托等。
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