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12 条记录 (耗时 0.017 秒)

    Segmented device for simultaneous delivery of multiple beneficial agents
    1.
    发明授权
    Segmented device for simultaneous delivery of multiple beneficial agents 失效
    用于同时传送多个有益试剂的分段装置

    公开(公告)号：US5443461A

    公开(公告)日：1995-08-22

    申请号：US114800

    申请日：1993-08-31

    申请人： Linda E. Atkinson ,  John T. Dunn ,  Robert M. Gale ,  David L. Rivera

    发明人： Linda E. Atkinson ,  John T. Dunn ,  Robert M. Gale ,  David L. Rivera

    IPC分类号： A61K9/22 ,  A61K9/48

    CPC分类号： A61K9/4808

    摘要： Diffusional delivery devices are constructed in two or more compartments, each containing a separate drug or other beneficial agent, and each arranged to permit diffusion of the agent out of the device through an individually-characterized agent-permeable wall segment. The diffusion rates of the various agents relative to one another are set and controlled by the parameters of the individual wall segments, such as the surface area of the wall segment, the average thickness of the wall segment, and the permeability of the wall segment for the particular agent. The permeability may be varied by variations in the chemical composition of the wall segment. Using these parameters rather than blending the agents at calculated ratios in a single formulation for diffusion through a single wall permits a wider range of, and greater flexibility in, variation between the diffusion rates of the different agents. This is of value when the simultaneous administration of agents at a specified ratio is desired.

    摘要翻译： 扩散递送装置构造在两个或更多个隔室中，每个隔室含有单独的药物或其它有益剂，并且每个隔室布置成允许药剂通过单独表征的药剂可渗透壁段从装置中扩散出设备。 各种试剂相对于彼此的扩散速率由单个壁段的参数设定和控制，例如壁段的表面积，壁段的平均厚度和壁段的渗透率 特定的代理。 渗透率可以通过壁段的化学组成的变化而变化。 使用这些参数而不是以单一制剂计算的比例混合试剂以通过单个壁扩散，允许不同试剂的扩散速率之间的变化范围更宽且更大的灵活性。 当需要以特定比例同时施用药剂时，这是有价值的。

    Transdermal contraceptive formulations methods and devices
    3.
    发明授权
    Transdermal contraceptive formulations methods and devices 失效
    透皮避孕配方法及装置

    公开(公告)号：US5512292A

    公开(公告)日：1996-04-30

    申请号：US361356

    申请日：1994-12-21

    申请人： Robert M. Gale ,  Diane E. Nedberge ,  Linda E. Atkinson

    发明人： Robert M. Gale ,  Diane E. Nedberge ,  Linda E. Atkinson

    IPC分类号： A61K9/00 ,  A61K9/70 ,  A61K31/565 ,  A61K47/14 ,  A61F13/02

    CPC分类号： A61K9/7084 ,  A61K31/565 ,  A61K31/567 ,  A61K47/14 ,  A61K9/0014 ,  Y10S514/843 ,  Y10S514/947

    摘要： The present invention provides compositions and methods for the transdermal administration of a contraceptively effective amount of gestodene and estrogen, such as ethinyl estradiol, in combination, together with a suitable permeation enhancer. The amount of the estrogen codelivered is kept at an about constant and contraceptively effective rate while the amount of gestogen codelivered varies depending on the phase of the menstrual cycle but remains at a contraceptively effective rate. The size of the system may also vary depending on the amount of gestogeno be delivered.

    摘要翻译： 本发明提供组合物和合适的透皮给药避孕有效量的孕二烯酮和雌激素（例如乙炔雌二醇）的组合物和方法以及合适的渗透增强剂。 雌激素编码的数量保持在大约恒定和避孕有效率，而代谢产物的数量根据月经周期的相位而变化，但仍然是避孕有效率。 系统的尺寸也可以根据递送的gestogeno的量而变化。