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公开(公告)号：US08017135B1
公开(公告)日：2011-09-13
申请号：US10770885
申请日：2004-02-02
IPC分类号： A61K9/00
CPC分类号： A61K9/0051 , A61K47/54
摘要： Methods are provided for treating pathological conditions of ocular tissue by administering to subjects in need thereof therapeutically active complexes that include amphiphilic analogs of the therapeutically active agents. These complexes exhibit low water solubility and are isolated in either crystalline form, amorphous form, or a combination thereof, within a well-defined particle size range. Administration of such complexes of therapeutically active agents to ocular tissue results in extended release of the therapeutically active agent. Indeed, certain complexes persist for up to about 20-30 weeks or longer after intravitreal injection, thereby providing a sustained release of therapeutically active agent into the structures of the eye.
摘要翻译： 提供了通过向有需要的受试者施用包括治疗活性剂的两亲类似物的治疗活性复合物来治疗眼组织的病理学病症的方法。 这些配合物表现出低水溶性，并且在明确的粒度范围内以结晶形式，无定形形式或其组合分离。 将这种治疗活性剂复合物施用于眼组织导致治疗活性剂的延长释放。 事实上，某些复合物在玻璃体内注射后持续长达约20-30周或更长时间，从而提供治疗活性剂持续释放到眼睛结构中。
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公开(公告)号：US20090208556A1
公开(公告)日：2009-08-20
申请号：US11665557
申请日：2005-10-31
申请人： William Freeman , Michael J. Sailor , Lingyun Cheng , Frederique Cunin , Emily Anglin , Yang Yang Li
发明人： William Freeman , Michael J. Sailor , Lingyun Cheng , Frederique Cunin , Emily Anglin , Yang Yang Li
IPC分类号： A61F9/00
CPC分类号： A61K9/0048 , A61F9/0017 , A61K9/0051 , A61K9/1611 , A61K9/7007 , A61K31/573 , A61K47/24 , A61K47/26 , A61P27/02
摘要： A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.
摘要翻译： 一种用于将特定药物或药物递送到眼睛的特定位置的微创控制药物递送系统，所述系统包括多孔膜模板，所述多孔膜模板具有构造和尺寸以至少部分地在其中至少部分地接收至少一种药物的孔，并且其中所述模板是 尺寸设计成被输送到眼睛中或眼睛上。
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