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公开(公告)号：US20090208556A1
公开(公告)日：2009-08-20
申请号：US11665557
申请日：2005-10-31
申请人： William Freeman , Michael J. Sailor , Lingyun Cheng , Frederique Cunin , Emily Anglin , Yang Yang Li
发明人： William Freeman , Michael J. Sailor , Lingyun Cheng , Frederique Cunin , Emily Anglin , Yang Yang Li
IPC分类号： A61F9/00
CPC分类号： A61K9/0048 , A61F9/0017 , A61K9/0051 , A61K9/1611 , A61K9/7007 , A61K31/573 , A61K47/24 , A61K47/26 , A61P27/02
摘要： A minimally invasive controlled drug delivery system for delivering a particular drug or drugs to a particular location of the eye, the system including a porous film template having pores configured and dimensioned to at least partially receive at least one drug therein, and wherein the template is dimensioned to be delivered into or onto the eye.
摘要翻译： 一种用于将特定药物或药物递送到眼睛的特定位置的微创控制药物递送系统，所述系统包括多孔膜模板，所述多孔膜模板具有构造和尺寸以至少部分地在其中至少部分地接收至少一种药物的孔，并且其中所述模板是 尺寸设计成被输送到眼睛中或眼睛上。
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2.发明授权Nanostructured casting of organic and bio-polymers in porous silicon templates 有权有机和生物聚合物在多孔硅模板中的纳米结构铸造公开(公告)号：US07713778B2
公开(公告)日：2010-05-11
申请号：US10544801
申请日：2004-02-13
申请人： Yang Yang Li , Frederique Cunin , Michael J. Sailor , Jamie R. Link , Ting Gao
发明人： Yang Yang Li , Frederique Cunin , Michael J. Sailor , Jamie R. Link , Ting Gao
IPC分类号： H01L21/00
CPC分类号： B29D11/00346 , B29D11/0074 , B81B2201/06 , B81B2203/0361 , B81C99/0085 , B81C2201/0115 , B81C2201/034 , Y10S977/921
摘要： A method of generating three-dimensional nanostructures that includes providing a silicon substrate, creating a porous silicon template from the silicon substrate, wherein the template is created to have a predetermined configuration, depositing a predetermined material on the porous silicon template, and removing the porous silicon template from the deposited material to leave a freestanding nanostructure.
摘要翻译： 一种产生三维纳米结构的方法，其包括提供硅衬底，从所述硅衬底产生多孔硅模板，其中所述模板被创建为具有预定构型，在所述多孔硅模板上沉积预定材料，以及除去所述多孔硅模板 硅模板从沉积的材料离开独立的纳米结构。
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公开(公告)号：US08765484B2
公开(公告)日：2014-07-01
申请号：US10503217
申请日：2003-01-31
IPC分类号： G01N33/50 , G01N33/552 , G01N21/55 , G01N37/00 , C12Q1/68
CPC分类号： G06K19/06084 , B05D1/00 , B05D2451/00 , G01N21/31 , G01N21/45 , G06K19/0614 , G09F3/00 , Y10T436/13 , Y10T436/143333 , Y10T436/144444
摘要： The invention concerns a particle having a code embedded in its physical structure by refractive index changes between different regions of the particle. In preferred embodiments, a thin film possesses porosity that varies in a manner to produce a code detectable in the reflectivity spectrum.
摘要翻译： 本发明涉及一种具有通过粒子的不同区域之间的折射率变化嵌入其物理结构中的代码的粒子。 在优选实施例中，薄膜具有以产生在反射率谱中可检测的代码的方式变化的孔隙率。
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公开(公告)号：US08206780B2
公开(公告)日：2012-06-26
申请号：US11791933
申请日：2005-12-14
CPC分类号： B01J2/22 , Y10S977/70 , Y10S977/895 , Y10T428/2982
摘要： A method for forming photonic particles, where the method includes the steps of preparing a porous photonic material layer, patterning a soluble polymer on the porous photonic material layer, leaving dividing portions of the material layer untreated, infusing the polymer into the material layer, and removing the dividing portions of the material to obtain the photonic particles.
摘要翻译： 一种形成光子粒子的方法，其中该方法包括制备多孔光子材料层的步骤，在多孔光子材料层上构图可溶性聚合物，使材料层的分割部分未经处理，将聚合物注入材料层，以及 去除材料的分割部分以获得光子粒子。
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公开(公告)号：US08097173B2
公开(公告)日：2012-01-17
申请号：US11632914
申请日：2005-07-18
申请人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
发明人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure that produces a predetermined optical response and magnetic material adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译： 本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。 本发明的优选颗粒具有产生预定光学响应的多孔结构和附着于颗粒的磁性材料。 另一个优选的颗粒是两亲性的。 由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。 本磁性颗粒的磁性使颗粒本身受到操纵，例如振动，移动和重新取向。 多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。
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公开(公告)号：US20080145513A1
公开(公告)日：2008-06-19
申请号：US11791933
申请日：2005-12-14
CPC分类号： B01J2/22 , Y10S977/70 , Y10S977/895 , Y10T428/2982
摘要： A method for forming photonic particles, where the method includes the steps of preparing a porous photonic material layer, patterning a soluble polymer on the porous photonic material layer, leaving dividing portions of the material layer untreated, infusing the polymer into the material layer, and removing the dividing portions of the material to obtain the photonic particles.
摘要翻译： 一种形成光子粒子的方法，其中该方法包括制备多孔光子材料层的步骤，在多孔光子材料层上构图可溶性聚合物，使材料层的分割部分未经处理，将聚合物注入材料层，以及 去除材料的分割部分以获得光子粒子。
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7.发明授权Porous photonic crystal with light scattering domains and methods of synthesis and use thereof 有权具有光散射域的多孔光子晶体及其合成和使用方法公开(公告)号：US07903239B2
公开(公告)日：2011-03-08
申请号：US11665613
申请日：2005-10-19
申请人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
发明人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
IPC分类号： G01N1/00
CPC分类号： G01N21/4738 , G01N33/5005 , G01N33/54373
摘要： The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.
摘要翻译： 本发明包括用于确定分析物的细胞形态和/或化学组成的传感器和感测方法。 表现出第一光信号的多孔基材暴露于目标分析物，随后监测光信号的变化。 更具体地，例如使用具有明确且高度可调谐的反射率或透射光谱的光子或多孔基底，例如多孔硅（Si），多孔氧化铝，多孔Ge，多孔GaAs，多孔SiO 2和多孔聚合物。 将多孔或光子底物暴露于分析物，例如细胞或其他大分子，并随时间观察散射光的变化，以确定使用底物的分析物的细胞形态和/或化学组成。
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公开(公告)号：US20080296255A1
公开(公告)日：2008-12-04
申请号：US11632914
申请日：2005-07-18
申请人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
发明人： Michael J. Sailor , Yang Yang Li , Nathan Trujillo , Jason Dorvee
IPC分类号： H01L21/311 , B32B5/18
CPC分类号： G01N21/31 , B22F1/0003 , B22F1/025 , B22F2998/10 , B82Y20/00 , G02B6/1225 , G02B26/004 , G02F1/09 , H01F1/0063 , Y10S977/838 , Y10S977/96 , Y10S977/962 , Y10T428/29 , Y10T428/2982 , Y10T428/2991 , Y10T428/31 , Y10T428/32 , B22F3/114 , B22F9/04
摘要： The invention provides porous particles that produce a predetermined optical response and that may be manipulated magnetically. A preferred particle of the invention has a porous structure that produces a predetermined optical response and magnetic material adhered to the particle. Another preferred particle is amphiphilic. The optical response provided by a particle of the invention enables particles of the invention to be used in sensing, labeling, signaling, display and many other applications. The magnetic nature of the present magnetic particles permits the particles themselves to be manipulated, e.g., vibrated, moved and re-oriented. The porous particles can also be used to control, move, and/or deliver small volumes of liquids and solids associated with the particles.
摘要翻译： 本发明提供产生预定光学响应且可以磁性操作的多孔颗粒。 本发明的优选颗粒具有产生预定光学响应的多孔结构和附着于颗粒的磁性材料。 另一个优选的颗粒是两亲性的。 由本发明的颗粒提供的光学响应使得本发明的颗粒可用于感测，标记，信号传递，显示和许多其它应用。 本磁性颗粒的磁性使粒子本身受到操纵，例如振动，移动和重新取向。 多孔颗粒也可用于控制，移动和/或传送与颗粒相关的小体积的液体和固体。
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9.发明申请Porous Photonic Crystal with Light Scattering Domains and Methods of Synthesis and Use Thereof 有权具有光散射域的多孔光子晶体及其合成和使用方法公开(公告)号：US20080212068A1
公开(公告)日：2008-09-04
申请号：US11665613
申请日：2005-10-19
申请人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
发明人： Michael J. Sailor , Michael P. Schwartz , Sara Alvarez , Sangeeta Bhatia , Austin Derfus , Benjamin Migliori , Lin Chao , Yang Yang Li , Rebecca Campbell , Jason Dorvee , Ulla Camilla Rang
IPC分类号： G01N1/00
CPC分类号： G01N21/4738 , G01N33/5005 , G01N33/54373
摘要： The invention includes sensors and sensing methods for determining cell morphology and/or chemical composition of an analyte. A porous substrate exhibiting a first optical signal is exposed to a target analyte and subsequently monitored for changes in the optical signal. More specifically, a photonic or porous substrate having a well-defined and highly tunable reflectivity or transmission spectrum, such as porous silicon (Si), porous alumina, porous Ge, porous GaAs, porous SiO2 and porous polymer, is used for example. A porous or photonic substrate is exposed to an analyte, such as a cell or other macromolecule, and changes in the scattered light are observed over time to determine cell morphology and/or chemical composition of the analyte using the substrate.
摘要翻译： 本发明包括用于确定分析物的细胞形态和/或化学组成的传感器和感测方法。 表现出第一光信号的多孔基材暴露于目标分析物，随后监测光信号的变化。 更具体地，例如使用具有明确且高度可调谐的反射率或透射光谱的光子或多孔基底，例如多孔硅（Si），多孔氧化铝，多孔Ge，多孔GaAs，多孔SiO 2和多孔聚合物。 将多孔或光子底物暴露于分析物，例如细胞或其他大分子，并随时间观察散射光的变化，以确定使用底物的分析物的细胞形态和/或化学组成。
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10.发明授权Temperature response sensing and classification of analytes with porous optical films 有权多孔光学薄膜的分析物的温度响应感测和分类公开(公告)号：US09007593B2
公开(公告)日：2015-04-14
申请号：US13811147
申请日：2011-07-19
申请人： Michael J. Sailor , Brian H King , Sadafumi Noda
发明人： Michael J. Sailor , Brian H King , Sadafumi Noda
CPC分类号： G01N21/25 , G01N21/171 , Y10T436/153333
摘要： Methods and systems of the invention can determine the identity and quantity of analytes in a vapor. In preferred methods, a porous optical film is exposed to vapor which contains analyte. The porous optical film is heated and its optical response is monitored during heating. An optical response observed via heating can determine the identity and/or quantity of the analyte. In preferred embodiments, optical response during a thermal pulse is compared to a database of sensor responses that are characteristic of various analytes. Preferred methods are conducted a relatively low temperatures, for example below about 200° C. In preferred methods, a heating and cooling cycle produces a hysteresis curve in the optical response that is indicative of analytes. In preferred embodiments, a thermal reset pulse resets the porous optical film for later use and also provides an optical response that can be used for sensing.
摘要翻译： 本发明的方法和系统可以确定蒸汽中分析物的身份和数量。 在优选的方法中，多孔光学膜暴露于含有分析物的蒸汽。 加热多孔光学膜并在加热期间监测其光学响应。 通过加热观察到的光学响应可以确定分析物的身份和/或数量。 在优选实施例中，将热脉冲期间的光学响应与各种分析物的特征的传感器响应的数据库进行比较。 优选的方法进行相对较低的温度，例如低于约200℃。在优选的方法中，加热和冷却循环在指示分析物的光学响应中产生滞后曲线。 在优选实施例中，热复位脉冲复位多孔光学膜用于稍后使用，并且还提供可用于感测的光学响应。
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