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公开(公告)号:US20050014633A1
公开(公告)日:2005-01-20
申请号:US10888820
申请日:2004-07-09
申请人: Albert Chan , Liqin Qiu
发明人: Albert Chan , Liqin Qiu
CPC分类号: C07F15/008 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , C07F9/65527 , C07F15/0053
摘要: The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R′ is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
摘要翻译: 本发明提供下式的化合物其中R是任选取代的低级烷基,环烷基或芳基; R'是烷基或芳基; n为0或1或2的整数; 或其对映体; 或其对映体混合物。 式(I)化合物是桥连的C2对称联苯二膦类似物,因此可用作配体以产生可用于各种不对称反应的手性过渡金属催化剂。 根据本文公开的方法,本发明的化合物可以以高非对映异构体和光学纯度容易地获得。
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公开(公告)号:US07094725B2
公开(公告)日:2006-08-22
申请号:US10888820
申请日:2004-07-09
申请人: Albert Sun-Chi Chan , Liqin Qiu
发明人: Albert Sun-Chi Chan , Liqin Qiu
IPC分类号: B01J31/00
CPC分类号: C07F15/008 , B01J31/2409 , B01J2231/643 , B01J2231/645 , B01J2531/0266 , B01J2531/80 , C07F9/65527 , C07F15/0053
摘要: The present invention provides compounds of the formula wherein R is optionally substituted lower alkyl, cycloalkyl or aryl; R′ is alkyl or aryl; n is zero or an integer of 1 or 2; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of formula (I) are bridged C2-symmetric biphenyldiphosphine analogs and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions. The compounds of the present invention are easily accessible in high diastereomeric and optical purity according to the methods disclosed herein.
摘要翻译: 本发明提供下式的化合物其中R是任选取代的低级烷基,环烷基或芳基; R'是烷基或芳基; n为0或1或2的整数; 或其对映体; 或其对映体混合物。 式(I)化合物是桥连的C 2 - 对称联苯基二膦类似物,因此可用作配体以产生可用于各种不对称反应的手性过渡金属催化剂。 根据本文公开的方法,本发明的化合物可以以高非对映异构体和光学纯度容易地获得。
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