公开(公告)号：US20130225516A1

公开(公告)日：2013-08-29

申请号：US13774159

申请日：2013-02-22

申请人： Mark David Soll ,  James Pate ,  Lisa A. Baker

发明人： Mark David Soll ,  James Pate ,  Lisa A. Baker

IPC分类号： A61K47/22 ,  A61K47/14 ,  A61K45/06 ,  A61K31/415 ,  A61K31/215

CPC分类号： A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

摘要： The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methylpyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methylpyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methylpyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

摘要翻译： 本文公开的主题涉及稳定的，高效的局部制剂，其包含氯菊酯，氟虫腈和溶剂体系，其足以溶解这两种活性成分并限制氟虫腈对其砜的降解，以及它们在局部应用于动物和 环境。 有用的制剂包含约30％至约55％（w / w）氯菊酯和约2至15％（w / w）氟虫腈和包含N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸 酯或中性油，其中N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸酯或中性油以重量比为约1:2.0至约1:3.5存在，二醇，二醇醚， 乙二醇酯，脂肪酸酯或中性油加到正 - 甲基吡咯烷酮中。 已经发现当以所述量组合时，这两种活性物质具有针对稳定蝇的意想不到的增强的驱避活性。 然而，本文所述的制剂提供了在施用于动物之后保持协同浓度的溶解能力和稳定性。

公开(公告)号：US09457088B2

公开(公告)日：2016-10-04

申请号：US13774159

申请日：2013-02-22

申请人： Mark David Soll ,  James Pate ,  Lisa A. Baker

发明人： Mark David Soll ,  James Pate ,  Lisa A. Baker

IPC分类号： A61K47/22 ,  A61K31/215 ,  A61K31/415 ,  A61K45/06 ,  A61K47/14 ,  A01N53/00 ,  A61K9/00 ,  A61K47/08 ,  A61K47/18 ,  A01N47/02

CPC分类号： A61K31/415 ,  A01N25/02 ,  A01N25/22 ,  A01N37/38 ,  A01N43/40 ,  A01N43/56 ,  A01N47/02 ,  A01N49/00 ,  A01N53/00 ,  A61K9/0017 ,  A61K31/201 ,  A61K31/215 ,  A61K31/216 ,  A61K31/4402 ,  A61K45/06 ,  A61K47/08 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/22 ,  A61K47/44 ,  A61K2300/00 ,  A01N2300/00

摘要： The subject matter disclosed herein is directed to stable, highly-effective topical formulations comprising permethrin, fipronil and a solvent system that is sufficient to solubilize these two active ingredients and limit degradation of fipronil to its sulfone, and their uses in topical applications on animals and the environment. Useful formulations comprise from about 30% to about 55% (w/w) permethrin and about 2 to 15% (w/w) fipronil and a solvent system that comprises N-methyl pyrrolidone and a glycol, glycol ether, glycol ester, fatty acid ester or neutral oil, wherein the N-methyl pyrrolidone and glycol, glycol ether, glycol ester, fatty acid ester or neutral oil are present in a weight:weight ratio of from about 1:2.0 to about 1:3.5, glycol, glycol ether, glycol ester, fatty acid ester or neutral oil to n-methyl pyrrolidone. These two actives when combined in the described amounts have been found to have unexpected enhanced repellent activity against stable fly. However, it is the formulations described herein that provide solvency and stability that maintain synergistic concentrations after application on an animal.

摘要翻译： 本文公开的主题涉及稳定，高效的局部制剂，其包含氯菊酯，氟虫腈和溶剂体系，其足以溶解这两种活性成分并限制氟虫腈对其砜的降解，以及它们在局部应用于动物和 环境。 有用的制剂包含约30％至约55％（w / w）苄氯菊酯和约2至15％（w / w）氟虫腈和包含N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪 酸酯或中性油，其中N-甲基吡咯烷酮和二醇，二醇醚，乙二醇酯，脂肪酸酯或中性油以重量比为约1:2.0至约1:3.5存在，乙二醇，乙二醇 醚，乙二醇酯，脂肪酸酯或中性油加到正甲基吡咯烷酮中。 已经发现当以所述量组合时，这两种活性物质具有针对稳定蝇的意想不到的增强的驱避活性。 然而，本文所述的制剂提供了在施用于动物之后保持协同浓度的溶解能力和稳定性。